Radiosensitization by Marine Sponge Agelas sp. Extracts in Hepatocellular Carcinoma Cells with Autophagy Induction
SCIE
SCOPUS
Cited 19 time in
WEB OF SCIENCE
Cited 21 time in
Scopus
-
Title
- Radiosensitization by Marine Sponge Agelas sp. Extracts in Hepatocellular Carcinoma Cells with Autophagy Induction
-
Author(s)
- Choi, C.; Son, A.; Lee, H.-S.; Lee, Y.-J.; Park, H.C.
- KIOST Author(s)
- Lee, Hyi Seung(이희승); Lee, Yeon Ju(이연주)
-
Alternative Author(s)
- 이희승; 이연주
-
Publication Year
- 2018
-
Abstract
- Although radiation therapy is an effective treatment modality in many cancers, there is an urgent need to develop therapeutic drugs capable of overcoming radioresistance or minimizing normal tissue toxicity. A wide variety of marine-derived bioactive compounds have been screened for anti-cancer drug discovery, but little is known regarding radiation therapy applications. In this study, six different extracts of marine sponges collected from the Micronesian sea were screened for anti-cancer and radiosensitizing activity. Two extracts derived from Agelas sponges collected off the coast of Kosrae and Chuuk, the Federated States of Micronesia significantly decreased clonogenic survival of hepatocellular carcinoma (HCC) cells after exposure to ionizing radiation (IR). The Agelas extracts augmented IR-induced apoptosis and accumulation of reactive oxygen species (ROS). Endoplasmic reticulum (ER) stress was increased via unfolded protein response stimulation, which induced autophagy. N-acetylcysteine, a ROS scavenger, diminished ER stress and autophagy induction effects. This result indicated that Agelas extracts may sensitize HCC cells to IR via ROS overproduction in vitro. Our findings suggest that the Agelas sp. may have potential utility in radiosensitizer development. © 2018 The Author(s).
-
ISSN
- 2045-2322
-
URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/1057
-
DOI
- 10.1038/s41598-018-24745-w
-
Bibliographic Citation
- Scientific Reports, v.8, no.1, 2018
-
Publisher
- Nature Publishing Group
-
Subject
- acetylcysteine; cell extract; radiosensitizing agent; reactive oxygen metabolite; Agelas; animal; apoptosis; autophagy; drug effect; endoplasmic reticulum stress; Federated States of Micronesia; human; liver cell carcinoma; liver tumor; metabolism; pathology; sponge (Porifera); tumor cell line; Acetylcysteine; Agelas; Animals; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Extracts; Cell Line, Tumor; Endoplasmic Reticulum Stress; Humans; Liver Neoplasms; Micronesia; Porifera; Radiation-Sensitizing Agents; Reactive Oxygen Species
-
Type
- Article
-
Language
- English
-
Document Type
- Article
- Files in This Item:
-
There are no files associated with this item.
Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.