Radiosensitization by Marine Sponge Agelas sp. Extracts in Hepatocellular Carcinoma Cells with Autophagy Induction SCIE SCOPUS

Cited 7 time in WEB OF SCIENCE Cited 8 time in Scopus
Title
Radiosensitization by Marine Sponge Agelas sp. Extracts in Hepatocellular Carcinoma Cells with Autophagy Induction
Author(s)
Choi, C.; Son, A.; Lee, H.-S.; Lee, Y.-J.; Park, H.C.
KIOST Author(s)
Lee, Hyi Seung(이희승)Lee, Yeon Ju(이연주)
Publication Year
2018
Abstract
Although radiation therapy is an effective treatment modality in many cancers, there is an urgent need to develop therapeutic drugs capable of overcoming radioresistance or minimizing normal tissue toxicity. A wide variety of marine-derived bioactive compounds have been screened for anti-cancer drug discovery, but little is known regarding radiation therapy applications. In this study, six different extracts of marine sponges collected from the Micronesian sea were screened for anti-cancer and radiosensitizing activity. Two extracts derived from Agelas sponges collected off the coast of Kosrae and Chuuk, the Federated States of Micronesia significantly decreased clonogenic survival of hepatocellular carcinoma (HCC) cells after exposure to ionizing radiation (IR). The Agelas extracts augmented IR-induced apoptosis and accumulation of reactive oxygen species (ROS). Endoplasmic reticulum (ER) stress was increased via unfolded protein response stimulation, which induced autophagy. N-acetylcysteine, a ROS scavenger, diminished ER stress and autophagy induction effects. This result indicated that Agelas extracts may sensitize HCC cells to IR via ROS overproduction in vitro. Our findings suggest that the Agelas sp. may have potential utility in radiosensitizer development. © 2018 The Author(s).
ISSN
2045-2322
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/1057
DOI
10.1038/s41598-018-24745-w
Bibliographic Citation
Scientific Reports, v.8, no.1, 2018
Publisher
Nature Publishing Group
Subject
acetylcysteine; cell extract; radiosensitizing agent; reactive oxygen metabolite; Agelas; animal; apoptosis; autophagy; drug effect; endoplasmic reticulum stress; Federated States of Micronesia; human; liver cell carcinoma; liver tumor; metabolism; pathology; sponge (Porifera); tumor cell line; Acetylcysteine; Agelas; Animals; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Extracts; Cell Line, Tumor; Endoplasmic Reticulum Stress; Humans; Liver Neoplasms; Micronesia; Porifera; Radiation-Sensitizing Agents; Reactive Oxygen Species
Type
Article
Language
English
Document Type
Article
Publisher
Nature Publishing Group
Related Researcher
Research Interests

Marine Natural Products,Organic Chemistry,해양천연물,유기화학

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