Anti-inflammation effects of 8-oxo-9-octadecenoic acid isolated from Undaria Peterseniana in lipopolysaccharide- stimulated macrophage cells SCIE SCOPUS

Cited 2 time in WEB OF SCIENCE Cited 7 time in Scopus
Title
Anti-inflammation effects of 8-oxo-9-octadecenoic acid isolated from Undaria Peterseniana in lipopolysaccharide- stimulated macrophage cells
Author(s)
Kang, M.-C.; Ham, Y.-M.; Heo, S.-J.; Yoon, S.-A.; Cho, S.-H.; Kwon, S.-H.; Jeong, M.S.; Jeon, Y.-J.; Sanjeewa, K.K.A.; Yoon, W.-J.; Kim, K.-N.
KIOST Author(s)
Heo, Soo Jin(허수진)
Publication Year
2018
Abstract
The aim of this study was to investigate the anti-inflammatory activity of 8-oxo-9-octadecenoic acid (OOA) isolated from Undaria peterseniana by examining its ability to inhibit the lipopolysaccharide (LPS)-induced production of inflammatory mediators in RAW 264.7 macrophage cells. We found that OOA significantly suppressed the LPS-induced production of nitric oxide (NO) and inflammatory cytokines. OOA downregulated the LPS-induced expression of inducible nitric oxide synthase and cyclooxygenase-2 proteins. With respect to proinflammatory signaling pathways, OOA inhibited LPS-induced mitogen-activated protein kinase signaling by inhibiting the phosphorylation of c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK). Moreover, OOA inhibited LPS-induced nuclear factor (NF)-κB signaling by reducing the phosphorylation of IκB-α and p50 proteins. These results indicate that OOA significantly reduces proinflammatory signaling, which results in reduced expression of cytokines and proinflammatory mediators. Taken together, these results suggest that OOA has potent anti-inflammatory effects and could be considered an effective anti-inflammatory agent. © 2018, Leibniz Research Centre for Working Environment and Human Factors. All rights reserved.
ISSN
1611-2156
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/1049
DOI
10.17179/excli2018-1422
Bibliographic Citation
EXCLI Journal, v.17, pp.775 - 783, 2018
Publisher
Leibniz Research Centre for Working Environment and Human Factors
Subject
8 oxo 9 octadecenoic acid; antiinflammatory agent; cyclooxygenase 2; I kappa B kinase alpha; immunoglobulin enhancer binding protein; inducible nitric oxide synthase; interleukin 6; lipopolysaccharide; mitogen activated protein kinase; nitric oxide; protein p50; stress activated protein kinase; tumor necrosis factor; unclassified drug; animal cell; animal cell culture; antiinflammatory activity; Article; cell viability; controlled study; cytokine production; down regulation; drug isolation; enzyme phosphorylation; high performance liquid chromatography; macrophage; mouse; nonhuman; protein expression; protein phosphorylation; RAW 264.7 cell line; signal transduction; Undaria; Undaria peterseniana; Western blotting
Keywords
8-Oxo-9-octadecenoic acid; Anti-inflammatory; Lipopolysaccharide; Macrophages; Undaria peterseniana
Type
Article
Language
English
Document Type
Article
Publisher
Leibniz Research Centre for Working Environment and Human Factors
Related Researcher
Research Interests

Marine Biotechnology,Marine Natural Products,Bioactivities,해양생물공학,해양천연물학,생리활성

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