Anti-inflammation effects of 8-oxo-9-octadecenoic acid isolated from Undaria Peterseniana in lipopolysaccharide- stimulated macrophage cells
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Title
- Anti-inflammation effects of 8-oxo-9-octadecenoic acid isolated from Undaria Peterseniana in lipopolysaccharide- stimulated macrophage cells
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Author(s)
- Kang, M.-C.; Ham, Y.-M.; Heo, S.-J.; Yoon, S.-A.; Cho, S.-H.; Kwon, S.-H.; Jeong, M.S.; Jeon, Y.-J.; Sanjeewa, K.K.A.; Yoon, W.-J.; Kim, K.-N.
- KIOST Author(s)
- Heo, Soo Jin(허수진)
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Alternative Author(s)
- 허수진
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Publication Year
- 2018
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Abstract
- The aim of this study was to investigate the anti-inflammatory activity of 8-oxo-9-octadecenoic acid (OOA) isolated from Undaria peterseniana by examining its ability to inhibit the lipopolysaccharide (LPS)-induced production of inflammatory mediators in RAW 264.7 macrophage cells. We found that OOA significantly suppressed the LPS-induced production of nitric oxide (NO) and inflammatory cytokines. OOA downregulated the LPS-induced expression of inducible nitric oxide synthase and cyclooxygenase-2 proteins. With respect to proinflammatory signaling pathways, OOA inhibited LPS-induced mitogen-activated protein kinase signaling by inhibiting the phosphorylation of c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK). Moreover, OOA inhibited LPS-induced nuclear factor (NF)-κB signaling by reducing the phosphorylation of IκB-α and p50 proteins. These results indicate that OOA significantly reduces proinflammatory signaling, which results in reduced expression of cytokines and proinflammatory mediators. Taken together, these results suggest that OOA has potent anti-inflammatory effects and could be considered an effective anti-inflammatory agent. © 2018, Leibniz Research Centre for Working Environment and Human Factors. All rights reserved.
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ISSN
- 1611-2156
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/1049
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DOI
- 10.17179/excli2018-1422
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Bibliographic Citation
- EXCLI Journal, v.17, pp.775 - 783, 2018
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Publisher
- Leibniz Research Centre for Working Environment and Human Factors
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Subject
- 8 oxo 9 octadecenoic acid; antiinflammatory agent; cyclooxygenase 2; I kappa B kinase alpha; immunoglobulin enhancer binding protein; inducible nitric oxide synthase; interleukin 6; lipopolysaccharide; mitogen activated protein kinase; nitric oxide; protein p50; stress activated protein kinase; tumor necrosis factor; unclassified drug; animal cell; animal cell culture; antiinflammatory activity; Article; cell viability; controlled study; cytokine production; down regulation; drug isolation; enzyme phosphorylation; high performance liquid chromatography; macrophage; mouse; nonhuman; protein expression; protein phosphorylation; RAW 264.7 cell line; signal transduction; Undaria; Undaria peterseniana; Western blotting
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Keywords
- 8-Oxo-9-octadecenoic acid; Anti-inflammatory; Lipopolysaccharide; Macrophages; Undaria peterseniana
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Type
- Article
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Language
- English
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Document Type
- Article
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