Bisphenol A Induces a Distinct Transcriptome Profile in the Male Fish of the Marine Medaka Oryzias javanicus SCIE SCOPUS KCI

Cited 7 time in WEB OF SCIENCE Cited 7 time in Scopus
Title
Bisphenol A Induces a Distinct Transcriptome Profile in the Male Fish of the Marine Medaka Oryzias javanicus
Author(s)
Kim, Bo-Mi; Jo, Ye Jin; Lee, Nayun; Lee, Nayoung; Woo, Seonock; Rhee, Jae-Sung; Yum, Seungshic
KIOST Author(s)
Jo, Yejin(조예진)Lee, Na Yun(이나윤)Yum, Seungshic(염승식)
Publication Year
2018-03
Abstract
While environmental concentration of bisphenol A (BPA) is ubiquitously detected in effluent and surface of freshwater, BPA has also been measured in coastal and marine ecosystems. To understand the effect of waterborne BPA on the transcriptome over time, male fish of the marine medaka Oryzias javanicus were exposed to 76 mu g/L of BPA for 72 h. Time-course microarray study identified differentially expressed transcripts upon BPA exposure in the liver tissues in a time-dependent manner. The primary effect of BPA treatment appears to be significantly upregulated mRNA expression of lipid metabolism (e.g. fatty acid process, lipid/lipoprotein biosynthesis and transport, cholesterol regulation), while genes involved in diverse biochemical and physiological processes were downregulated. In particular, vertebrate immunity relevant genes showed strong downregulated patterns across time-courses. This study provides preliminary insights into the transcriptional response of marine medaka male fish to waterborne BPA exposure and suggests a basis for uncovering the mode of action particularly with respect to endocrine disrupting chemicals (EDCs) such as BPA.
ISSN
1976-0280
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/1006
DOI
10.1007/s13206-017-2104-0
Bibliographic Citation
BIOCHIP JOURNAL, v.12, no.1, pp.25 - 37, 2018
Publisher
KOREAN BIOCHIP SOCIETY-KBCS
Subject
ENDOCRINE DISRUPTING CHEMICALS; CHORIOGENIN MESSENGER-RNA; JAPANESE MEDAKA; LIPID-METABOLISM; ENVIRONMENTAL SALINITY; AQUATIC ENVIRONMENT; LATIPES; GENE; EXPRESSION; BIOMARKER
Keywords
Marine medaka; Oryzias javanicus; Bisphenol A; Microarray; Transcriptome
Type
Article
Language
English
Document Type
Article
Publisher
KOREAN BIOCHIP SOCIETY-KBCS
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