Indole Alkaloids from Tropical Sponge Hyrtios sp as Isocitrate Lyase Inhibitors SCIE SCOPUS
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- Title
- Indole Alkaloids from Tropical Sponge Hyrtios sp as Isocitrate Lyase Inhibitors
- KIOST Author(s)
- Lee, Yeon Ju(이연주); Lee, Hyi Seung(이희승)
- Alternative Author(s)
- 박승일; 이연주; 이희승
- Publication Year
- 2018-06
- Abstract
- A new beta-carboline alkaloid, 3,4-dihydrohyrtiosulawesine (8), and fifteen known alkaloids were isolated from the tropical marine sponge Hyrtios sp. Among these known compounds, beta-ketoserotonin (10) has been isolated for the first time from a natural source. The structures of the isolated compounds were determined by spectroscopic analyses and comparison with literature values. Compound 8 displayed potent inhibitory activities against isocitrate lyase (IC50: 92.9 mu M) from Candida albicans.
- ISSN
- 1934-578X
- Bibliographic Citation
- NATURAL PRODUCT COMMUNICATIONS, v.13, no.6, pp.683 - 685, 2018
- Publisher
- NATURAL PRODUCTS INC
- Subject
- MARINE SPONGES; GLYOXYLATE CYCLE; BETA-CARBOLINES; ERECTUS
- Keywords
- Hyrtios sp.; beta-Carboline alkaloids; Isocitrate lyase
- Type
- Article
- Language
- English
- Document Type
- Article
- Files in This Item:
- There are no files associated with this item.
