Indole Alkaloids from Tropical Sponge Hyrtios sp as Isocitrate Lyase Inhibitors SCIE SCOPUS

Cited 3 time in WEB OF SCIENCE Cited 3 time in Scopus
Title
Indole Alkaloids from Tropical Sponge Hyrtios sp as Isocitrate Lyase Inhibitors
Author(s)
Park, Seung-Il; Lee, Yeon-Ju; Won, Hoshik; Oh, Ki-Bong; Lee, Hyi-Seung
KIOST Author(s)
Lee, Yeon Ju(이연주)Lee, Hyi Seung(이희승)
Publication Year
2018-06
Abstract
A new beta-carboline alkaloid, 3,4-dihydrohyrtiosulawesine (8), and fifteen known alkaloids were isolated from the tropical marine sponge Hyrtios sp. Among these known compounds, beta-ketoserotonin (10) has been isolated for the first time from a natural source. The structures of the isolated compounds were determined by spectroscopic analyses and comparison with literature values. Compound 8 displayed potent inhibitory activities against isocitrate lyase (IC50: 92.9 mu M) from Candida albicans.
ISSN
1934-578X
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/890
Bibliographic Citation
NATURAL PRODUCT COMMUNICATIONS, v.13, no.6, pp.683 - 685, 2018
Publisher
NATURAL PRODUCTS INC
Subject
MARINE SPONGES; GLYOXYLATE CYCLE; BETA-CARBOLINES; ERECTUS
Keywords
Hyrtios sp.; beta-Carboline alkaloids; Isocitrate lyase
Type
Article
Language
English
Document Type
Article
Publisher
NATURAL PRODUCTS INC
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