Regionalized nervous system in Hydra and the mechanism of its development SCIE SCOPUS

Cited 8 time in WEB OF SCIENCE Cited 7 time in Scopus
Title
Regionalized nervous system in Hydra and the mechanism of its development
Author(s)
Noro, Yukihiko; Yum, Seungshic; Nishimiya-Fujisawa, Chiemi; Busse, Christina; Shimizu, Hiroshi; Mineta, Katsuhiko; Zhang, Xiaoming; Holstein, Thomas W.; David, Charles N.; Gojobori, Takashi; Fujisawa, Toshitaka
KIOST Author(s)
Yum, Seung Shic(염승식)
Publication Year
2019-01
Abstract
The last common ancestor of Bilateria and Cnidaria is considered to develop a nervous system over 500 million years ago. Despite the long course of evolution, many of the neuron-related genes, which are active in Bilateria, are also found in the cnidarian Hydra. Thus, Hydra is a good model to study the putative primitive nervous system in the last common ancestor that had the great potential to evolve to a more advanced one. Regionalization of the nervous system is one of the advanced features of bilaterian nervous system. Although a regionalized nervous system is already known to be present in Hydra, its developmental mechanisms are poorly understood. In this study we show how it is formed and maintained, focusing on the neuropeptide Hym-176 gene and its paralogs. First, we demonstrate that four axially localized neuron subsets that express different combination of the neuropeptide Hym-176 gene and its paralogs cover almost an entire body, forming a regionalized nervous system in Hydra. Second, we show that positional information governed by the Wnt signaling pathway plays a key role in determining the regional specificity of the neuron subsets as is the case in bilaterians. Finally, we demonstrated two basic mechanisms, regionally restricted new differentiation and phenotypic conversion, both of which are in part conserved in bilaterians, are involved in maintaining boundaries between the neuron subsets. Therefore, this study is the first comprehensive analysis of the anatomy and developmental regulation of the divergently evolved and axially regionalized peptidergic nervous system in Hydra, implicating an ancestral origin of neural regionalization.
ISSN
1567-133X
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/703
DOI
10.1016/j.gep.2019.01.003
Bibliographic Citation
GENE EXPRESSION PATTERNS, v.31, pp.42 - 59, 2019
Publisher
ELSEVIER SCIENCE BV
Subject
CELL-CYCLE KINETICS; VASOPRESSIN-LIKE IMMUNOREACTIVITY; ADULT HYDRA; NEURON DIFFERENTIATION; TENTACLE MORPHOGENESIS; SIGNALING PATHWAY; GENETIC-ANALYSIS; TISSUE DYNAMICS; WHOLE-MOUNT; EXPRESSION
Keywords
Hydra; Regionalized nervous system; Wnt; Homeotic transformation; Transgenic reporter line
Type
Article
Language
English
Document Type
Article
Publisher
ELSEVIER SCIENCE BV
Related Researcher
Research Interests

Marine Genomics,Environmental Genomics,Novel biomaterials,해양생물유전체,생태환경유전체,바이오신소재

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