MD001, a Novel Peroxisome Proliferator-activated Receptor alpha/gamma Agonist, Improves Glucose and Lipid Metabolism SCIE SCOPUS

DC Field Value Language
dc.contributor.author Kim, Seok-Ho -
dc.contributor.author Hong, Shin Hee -
dc.contributor.author Park, Young-Joon -
dc.contributor.author Sung, Jong-Hyuk -
dc.contributor.author Suh, Wonhee -
dc.contributor.author Lee, Kyeong Won -
dc.contributor.author Jung, Kiwon -
dc.contributor.author Lim, Changjin -
dc.contributor.author Kim, Jin-Hee -
dc.contributor.author Kim, Hyoungsu -
dc.contributor.author Park, Kyong Soo -
dc.contributor.author Park, Sang Gyu -
dc.date.accessioned 2020-04-16T08:15:22Z -
dc.date.available 2020-04-16T08:15:22Z -
dc.date.created 2020-02-19 -
dc.date.issued 2019-02-07 -
dc.identifier.issn 2045-2322 -
dc.identifier.uri https://sciwatch.kiost.ac.kr/handle/2020.kiost/679 -
dc.description.abstract Peroxisome proliferator-activated receptor (PPAR)-alpha/gamma dual agonists have been developed to treat metabolic diseases; however, most of them exhibit side effects such as body weight gain and oedema. Therefore, we developed a novel PPAR alpha/gamma dual agonist that modulates glucose and lipid metabolism without adverse effects. We synthesised novel compounds composed of coumarine and chalcone, determined their crystal structures, and then examined their binding affinity toward PPAR alpha/gamma. We investigated the expression of PPAR alpha and PPAR gamma target genes by chemicals in HepG2, differentiated 3T3-L1, and C2C12 cells. We examined the effect of chemicals on glucose and lipid metabolism in db/db mice. Only MD001 functions as a PPAR alpha/gamma dual agonist in vitro. MD001 increased the transcriptional activity of PPAR alpha and PPAR gamma, resulting in enhanced expression of genes related to beta-oxidation and fatty acid and glucose uptake. MD001 significantly improved blood metabolic parameters, including triglycerides, free fatty acids, and glucose, in db/db mice. In addition, MD001 ameliorated hepatic steatosis by stimulating beta-oxidation in vitro and in vivo. Our results demonstrated the beneficial effects of the novel compound MD001 on glucose and lipid metabolism as a PPAR alpha/gamma dual agonist. Consequently, MD001 may show potential as a novel drug candidate for the treatment of metabolic disorders. -
dc.description.uri 1 -
dc.language English -
dc.publisher NATURE PUBLISHING GROUP -
dc.subject ARYL METHYL ETHERS -
dc.subject PPAR-ALPHA-AGONIST -
dc.subject INSULIN SENSITIVITY -
dc.subject HEPATIC-DYSFUNCTION -
dc.subject ADIPOSE-TISSUE -
dc.subject HEART-FAILURE -
dc.subject FATTY LIVER -
dc.subject BODY-FAT -
dc.subject DEMETHYLATION -
dc.subject MURAGLITAZAR -
dc.title MD001, a Novel Peroxisome Proliferator-activated Receptor alpha/gamma Agonist, Improves Glucose and Lipid Metabolism -
dc.type Article -
dc.citation.title SCIENTIFIC REPORTS -
dc.citation.volume 9 -
dc.contributor.alternativeName 이경원 -
dc.identifier.bibliographicCitation SCIENTIFIC REPORTS, v.9 -
dc.identifier.doi 10.1038/s41598-018-38281-0 -
dc.identifier.scopusid 2-s2.0-85061235733 -
dc.identifier.wosid 000458017800124 -
dc.type.docType Article -
dc.description.journalClass 1 -
dc.subject.keywordPlus ARYL METHYL ETHERS -
dc.subject.keywordPlus PPAR-ALPHA-AGONIST -
dc.subject.keywordPlus INSULIN SENSITIVITY -
dc.subject.keywordPlus HEPATIC-DYSFUNCTION -
dc.subject.keywordPlus ADIPOSE-TISSUE -
dc.subject.keywordPlus HEART-FAILURE -
dc.subject.keywordPlus FATTY LIVER -
dc.subject.keywordPlus BODY-FAT -
dc.subject.keywordPlus DEMETHYLATION -
dc.subject.keywordPlus MURAGLITAZAR -
dc.relation.journalWebOfScienceCategory Multidisciplinary Sciences -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.relation.journalResearchArea Science & Technology - Other Topics -
Appears in Collections:
Marine Resources Research Division > Marine Biotechnology Research Center > 1. Journal Articles
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