Bromophenol (5-bromo-3,4-dihydroxybenzaldehyde) isolated from red alga Polysiphonia morrowii inhibits adipogenesis by regulating expression of adipogenic transcription factors and AMP-activated protein kinase activation in 3T3-L1 adipocytes SCIE SCOPUS

DC Field Value Language
dc.contributor.author Ko, Seok-Chun -
dc.contributor.author Ding, Yuling -
dc.contributor.author Kim, Junseong -
dc.contributor.author Ye, Bo-Ram -
dc.contributor.author Kim, Eun-A -
dc.contributor.author Jung, Won-Kyo -
dc.contributor.author Heo, Soo-Jin -
dc.contributor.author Lee, Seung-Hong -
dc.date.accessioned 2020-04-16T08:15:19Z -
dc.date.available 2020-04-16T08:15:19Z -
dc.date.created 2020-02-19 -
dc.date.issued 2019-03 -
dc.identifier.issn 0951-418X -
dc.identifier.uri https://sciwatch.kiost.ac.kr/handle/2020.kiost/670 -
dc.description.abstract The aim of the present study was to investigate the effect of 5-bromo-3,4-dihydroxybenzaldehyde (BD) isolated from Polysiphonia morrowii on adipogenesis and differentiation of 3T3-L1 preadipocytes into mature adipocytes and its possible mechanism of action. Levels of lipid accumulation and triglyceride were significantly lower in BD treated cells than those in untreated cells. In addition, BD treatment reduced protein expression levels of peroxisome proliferator-activated receptor-gamma, CCAAT/enhancer-binding proteins alpha, and sterol regulatory element-binding protein 1 compared with control (no treatment). It also reduced expression levels of adiponectin, leptin, fatty acid synthase, and fatty acid binding protein 4. AMP-activated protein kinase activation was found to be one specific mechanism involved in the effect of BD. These results demonstrate that BD possesses inhibitory effect on adipogenesis through activating AMP-activated protein kinase signal pathway. -
dc.description.uri 1 -
dc.language English -
dc.publisher WILEY -
dc.subject DIFFERENTIATION -
dc.subject ANTIOBESITY -
dc.subject PATHWAY -
dc.subject ACID -
dc.subject MICE -
dc.subject PHLOROTANNINS -
dc.subject GLUCOSAMINE -
dc.subject SEAWEED -
dc.subject OBESITY -
dc.subject CELLS -
dc.title Bromophenol (5-bromo-3,4-dihydroxybenzaldehyde) isolated from red alga Polysiphonia morrowii inhibits adipogenesis by regulating expression of adipogenic transcription factors and AMP-activated protein kinase activation in 3T3-L1 adipocytes -
dc.type Article -
dc.citation.endPage 744 -
dc.citation.startPage 737 -
dc.citation.title PHYTOTHERAPY RESEARCH -
dc.citation.volume 33 -
dc.citation.number 3 -
dc.contributor.alternativeName 김준성 -
dc.contributor.alternativeName 예보람 -
dc.contributor.alternativeName 김은아 -
dc.contributor.alternativeName 허수진 -
dc.identifier.bibliographicCitation PHYTOTHERAPY RESEARCH, v.33, no.3, pp.737 - 744 -
dc.identifier.doi 10.1002/ptr.6266 -
dc.identifier.scopusid 2-s2.0-85058861770 -
dc.identifier.wosid 000461067400024 -
dc.type.docType Article -
dc.description.journalClass 1 -
dc.subject.keywordPlus DIFFERENTIATION -
dc.subject.keywordPlus ANTIOBESITY -
dc.subject.keywordPlus PATHWAY -
dc.subject.keywordPlus ACID -
dc.subject.keywordPlus MICE -
dc.subject.keywordPlus PHLOROTANNINS -
dc.subject.keywordPlus GLUCOSAMINE -
dc.subject.keywordPlus SEAWEED -
dc.subject.keywordPlus OBESITY -
dc.subject.keywordPlus CELLS -
dc.subject.keywordAuthor 5-bromo-3,4-dihydroxybenzaldehyde (BD) -
dc.subject.keywordAuthor adipogenesis -
dc.subject.keywordAuthor AMPK -
dc.relation.journalWebOfScienceCategory Chemistry, Medicinal -
dc.relation.journalWebOfScienceCategory Pharmacology & Pharmacy -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.relation.journalResearchArea Pharmacology & Pharmacy -
Appears in Collections:
Jeju Research Institute > Jeju Marine Research Center > 1. Journal Articles
Jeju Research Institute > Jeju Bio Research Center > 1. Journal Articles
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