Bromophenol (5-bromo-3,4-dihydroxybenzaldehyde) isolated from red alga Polysiphonia morrowii inhibits adipogenesis by regulating expression of adipogenic transcription factors and AMP-activated protein kinase activation in 3T3-L1 adipocytes
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Title
- Bromophenol (5-bromo-3,4-dihydroxybenzaldehyde) isolated from red alga Polysiphonia morrowii inhibits adipogenesis by regulating expression of adipogenic transcription factors and AMP-activated protein kinase activation in 3T3-L1 adipocytes
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Author(s)
- Ko, Seok-Chun; Ding, Yuling; Kim, Junseong; Ye, Bo-Ram; Kim, Eun-A; Jung, Won-Kyo; Heo, Soo-Jin; Lee, Seung-Hong
- KIOST Author(s)
- Kim, Jun Seong(김준성); Kim, Eun A(김은아); Heo, Soo Jin(허수진)
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Alternative Author(s)
- 김준성; 예보람; 김은아; 허수진
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Publication Year
- 2019-03
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Abstract
- The aim of the present study was to investigate the effect of 5-bromo-3,4-dihydroxybenzaldehyde (BD) isolated from Polysiphonia morrowii on adipogenesis and differentiation of 3T3-L1 preadipocytes into mature adipocytes and its possible mechanism of action. Levels of lipid accumulation and triglyceride were significantly lower in BD treated cells than those in untreated cells. In addition, BD treatment reduced protein expression levels of peroxisome proliferator-activated receptor-gamma, CCAAT/enhancer-binding proteins alpha, and sterol regulatory element-binding protein 1 compared with control (no treatment). It also reduced expression levels of adiponectin, leptin, fatty acid synthase, and fatty acid binding protein 4. AMP-activated protein kinase activation was found to be one specific mechanism involved in the effect of BD. These results demonstrate that BD possesses inhibitory effect on adipogenesis through activating AMP-activated protein kinase signal pathway.
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ISSN
- 0951-418X
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/670
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DOI
- 10.1002/ptr.6266
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Bibliographic Citation
- PHYTOTHERAPY RESEARCH, v.33, no.3, pp.737 - 744, 2019
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Publisher
- WILEY
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Subject
- DIFFERENTIATION; ANTIOBESITY; PATHWAY; ACID; MICE; PHLOROTANNINS; GLUCOSAMINE; SEAWEED; OBESITY; CELLS
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Keywords
- 5-bromo-3,4-dihydroxybenzaldehyde (BD); adipogenesis; AMPK
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Type
- Article
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Language
- English
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Document Type
- Article
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