Bromophenol (5-bromo-3,4-dihydroxybenzaldehyde) isolated from red alga Polysiphonia morrowii inhibits adipogenesis by regulating expression of adipogenic transcription factors and AMP-activated protein kinase activation in 3T3-L1 adipocytes SCIE SCOPUS

Cited 7 time in WEB OF SCIENCE Cited 7 time in Scopus
Title
Bromophenol (5-bromo-3,4-dihydroxybenzaldehyde) isolated from red alga Polysiphonia morrowii inhibits adipogenesis by regulating expression of adipogenic transcription factors and AMP-activated protein kinase activation in 3T3-L1 adipocytes
Author(s)
Ko, Seok-Chun; Ding, Yuling; Kim, Junseong; Ye, Bo-Ram; Kim, Eun-A; Jung, Won-Kyo; Heo, Soo-Jin; Lee, Seung-Hong
KIOST Author(s)
Kim, Junseong(김준성)Kim, Eun A(김은아)Heo, Soo Jin(허수진)
Publication Year
2019-03
Abstract
The aim of the present study was to investigate the effect of 5-bromo-3,4-dihydroxybenzaldehyde (BD) isolated from Polysiphonia morrowii on adipogenesis and differentiation of 3T3-L1 preadipocytes into mature adipocytes and its possible mechanism of action. Levels of lipid accumulation and triglyceride were significantly lower in BD treated cells than those in untreated cells. In addition, BD treatment reduced protein expression levels of peroxisome proliferator-activated receptor-gamma, CCAAT/enhancer-binding proteins alpha, and sterol regulatory element-binding protein 1 compared with control (no treatment). It also reduced expression levels of adiponectin, leptin, fatty acid synthase, and fatty acid binding protein 4. AMP-activated protein kinase activation was found to be one specific mechanism involved in the effect of BD. These results demonstrate that BD possesses inhibitory effect on adipogenesis through activating AMP-activated protein kinase signal pathway.
ISSN
0951-418X
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/670
DOI
10.1002/ptr.6266
Bibliographic Citation
PHYTOTHERAPY RESEARCH, v.33, no.3, pp.737 - 744, 2019
Publisher
WILEY
Subject
DIFFERENTIATION; ANTIOBESITY; PATHWAY; ACID; MICE; PHLOROTANNINS; GLUCOSAMINE; SEAWEED; OBESITY; CELLS
Keywords
5-bromo-3,4-dihydroxybenzaldehyde (BD); adipogenesis; AMPK
Type
Article
Language
English
Document Type
Article
Publisher
WILEY
Related Researcher
Research Interests

Marine Life Science,Marine Natural Products,Bioactivities,해양생명과학,해양천연물학,생리활성

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