New Ophiobolin Derivatives from the Marine Fungus Aspergillus flocculosus and Their Cytotoxicities against Cancer Cells SCIE SCOPUS

Cited 24 time in WEB OF SCIENCE Cited 25 time in Scopus
Title
New Ophiobolin Derivatives from the Marine Fungus Aspergillus flocculosus and Their Cytotoxicities against Cancer Cells
Author(s)
Choi, Byeoung-Kyu; Phan Thi Hoai Trinh; Lee, Hwa-Sun; Choi, Byeong-Woo; Kang, Jong Soon; Ngo Thi Duy Ngoc; Tran Thi Thanh Van; Shin, Hee Jae
KIOST Author(s)
Lee, Hwa Sun(이화선)Shin, Hee Jae(신희재)
Alternative Author(s)
최병규; 이화선; 신희재
Publication Year
2019-06
Abstract
Five new sesterterpenes, 14,15-dehydro-6-epi-ophiobolin K (1), 14,15-dehydro- ophiobolin K (2), 14,15-dehydro-6-epi-ophiobolin G (3), 14,15-dehydro-ophiobolin G (4) and 14,15-dehydro-(Z)-14-ophiobolin G (5), together with four known ophiobolins (6-9) were isolated from the marine fungus Aspergillus flocculosus derived from the seaweed Padina sp. collected in Vietnam. The five new ophiobolins were first isolated as ophiobolin derivatives consisting of a fully unsaturated side chain. Their structures were elucidated via spectroscopic methods including 1D, 2D NMR and HR-ESIMS. The absolute configurations were determined by the comparison of chemical shifts and optical rotation values with those of known ophiobolins. All compounds (1-9) were then evaluated for their cytotoxicity against six cancer cell lines, HCT-15, NUGC-3, NCI-H23, ACHN, PC-3 and MDA-MB-231. All the compounds showed potent cytotoxicity with GI(50) values ranging from 0.14 to 2.01 mu M.
ISSN
1660-3397
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/615
DOI
10.3390/md17060346
Bibliographic Citation
MARINE DRUGS, v.17, no.6, 2019
Publisher
MDPI
Subject
NATURAL-PRODUCTS; ANTICANCER
Keywords
ophiobolins; marine fungus; Aspergillus flocculosus; anti-proliferation
Type
Article
Language
English
Document Type
Article
Publisher
MDPI
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