New bromotyrosine metabolites from the sponge Aplysinella rhax SCIE SCOPUS

DC Field Value Language
dc.contributor.author Shin, J -
dc.contributor.author Lee, HS -
dc.contributor.author Seo, Y -
dc.contributor.author Rho, JR -
dc.contributor.author Cho, KW -
dc.contributor.author Paul, VJ -
dc.date.accessioned 2020-04-21T08:25:40Z -
dc.date.available 2020-04-21T08:25:40Z -
dc.date.created 2020-01-28 -
dc.date.issued 2000-11-10 -
dc.identifier.issn 0040-4020 -
dc.identifier.uri https://sciwatch.kiost.ac.kr/handle/2020.kiost/6020 -
dc.description.abstract Four new bromotyrosine metabolites (3-6) along with the previously described compounds psammaplin A (1) and bisaprasin (2) have been isolated from the sponge Aplysinella rhax collected from Guam, Palau, and Pohnpei. Based upon the results of extensive spectroscopic analysis and chemical reaction, the structures of psammaplins A(1) (3) and A(2) (4) have been determined to be a N,N-dimethylguanidium salt of psammaplin A sulfate and its bis-N,N-dimethylguanidium disulfate derivative, respectively. Aplysinellin A (5) possesses an additional bromotyrosine-derived C-9 unit connected directly to the carbon framework of psammaplin A by a biphenylic Linkage while aplysinellin B (6) is the corresponding cyclic enol ether. These compounds exhibited moderate cytotoxicity and inhibitory activities against farnesyl protein transferase and leucine aminopeptidase. (C) 2000 Elsevier Science Ltd. All rights reserved. -
dc.description.uri 1 -
dc.language English -
dc.publisher PERGAMON-ELSEVIER SCIENCE LTD -
dc.subject PSAMMAPLYSILLA -
dc.subject SULFATE -
dc.title New bromotyrosine metabolites from the sponge Aplysinella rhax -
dc.type Article -
dc.citation.endPage 9077 -
dc.citation.startPage 9071 -
dc.citation.title TETRAHEDRON -
dc.citation.volume 56 -
dc.citation.number 46 -
dc.identifier.bibliographicCitation TETRAHEDRON, v.56, no.46, pp.9071 - 9077 -
dc.identifier.doi 10.1016/S0040-4020(00)00761-4 -
dc.identifier.scopusid 2-s2.0-0034634603 -
dc.identifier.wosid 000165207700013 -
dc.type.docType Article -
dc.description.journalClass 1 -
dc.subject.keywordPlus PSAMMAPLYSILLA -
dc.subject.keywordPlus SULFATE -
dc.subject.keywordAuthor bromotyrosines -
dc.subject.keywordAuthor psammaplins -
dc.subject.keywordAuthor aplysinellins -
dc.subject.keywordAuthor sponge -
dc.subject.keywordAuthor Aplysinella rhax -
dc.relation.journalWebOfScienceCategory Chemistry, Organic -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.relation.journalResearchArea Chemistry -
Appears in Collections:
Marine Environmental & Climate Research Division > Marine Ecosystem Research Center > 1. Journal Articles
Marine Resources Research Division > Marine Biotechnology Research Center > 1. Journal Articles
Files in This Item:
There are no files associated with this item.

qrcode

Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse