New bromotyrosine metabolites from the sponge Aplysinella rhax SCIE SCOPUS
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, J | - |
dc.contributor.author | Lee, HS | - |
dc.contributor.author | Seo, Y | - |
dc.contributor.author | Rho, JR | - |
dc.contributor.author | Cho, KW | - |
dc.contributor.author | Paul, VJ | - |
dc.date.accessioned | 2020-04-21T08:25:40Z | - |
dc.date.available | 2020-04-21T08:25:40Z | - |
dc.date.created | 2020-01-28 | - |
dc.date.issued | 2000-11-10 | - |
dc.identifier.issn | 0040-4020 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/6020 | - |
dc.description.abstract | Four new bromotyrosine metabolites (3-6) along with the previously described compounds psammaplin A (1) and bisaprasin (2) have been isolated from the sponge Aplysinella rhax collected from Guam, Palau, and Pohnpei. Based upon the results of extensive spectroscopic analysis and chemical reaction, the structures of psammaplins A(1) (3) and A(2) (4) have been determined to be a N,N-dimethylguanidium salt of psammaplin A sulfate and its bis-N,N-dimethylguanidium disulfate derivative, respectively. Aplysinellin A (5) possesses an additional bromotyrosine-derived C-9 unit connected directly to the carbon framework of psammaplin A by a biphenylic Linkage while aplysinellin B (6) is the corresponding cyclic enol ether. These compounds exhibited moderate cytotoxicity and inhibitory activities against farnesyl protein transferase and leucine aminopeptidase. (C) 2000 Elsevier Science Ltd. All rights reserved. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | PSAMMAPLYSILLA | - |
dc.subject | SULFATE | - |
dc.title | New bromotyrosine metabolites from the sponge Aplysinella rhax | - |
dc.type | Article | - |
dc.citation.endPage | 9077 | - |
dc.citation.startPage | 9071 | - |
dc.citation.title | TETRAHEDRON | - |
dc.citation.volume | 56 | - |
dc.citation.number | 46 | - |
dc.contributor.alternativeName | 신종헌 | - |
dc.contributor.alternativeName | 이희승 | - |
dc.contributor.alternativeName | 서영완 | - |
dc.contributor.alternativeName | 노정래 | - |
dc.contributor.alternativeName | 조기웅 | - |
dc.identifier.bibliographicCitation | TETRAHEDRON, v.56, no.46, pp.9071 - 9077 | - |
dc.identifier.doi | 10.1016/S0040-4020(00)00761-4 | - |
dc.identifier.scopusid | 2-s2.0-0034634603 | - |
dc.identifier.wosid | 000165207700013 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PSAMMAPLYSILLA | - |
dc.subject.keywordPlus | SULFATE | - |
dc.subject.keywordAuthor | bromotyrosines | - |
dc.subject.keywordAuthor | psammaplins | - |
dc.subject.keywordAuthor | aplysinellins | - |
dc.subject.keywordAuthor | sponge | - |
dc.subject.keywordAuthor | Aplysinella rhax | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |