New bromotyrosine metabolites from the sponge Aplysinella rhax SCIE SCOPUS

Cited 49 time in WEB OF SCIENCE Cited 53 time in Scopus
Title
New bromotyrosine metabolites from the sponge Aplysinella rhax
Author(s)
Shin, J; Lee, HS; Seo, Y; Rho, JR; Cho, KW; Paul, VJ
KIOST Author(s)
Lee, Hyi Seung(이희승)
Alternative Author(s)
신종헌; 이희승; 서영완; 노정래; 조기웅
Publication Year
2000-11-10
Abstract
Four new bromotyrosine metabolites (3-6) along with the previously described compounds psammaplin A (1) and bisaprasin (2) have been isolated from the sponge Aplysinella rhax collected from Guam, Palau, and Pohnpei. Based upon the results of extensive spectroscopic analysis and chemical reaction, the structures of psammaplins A(1) (3) and A(2) (4) have been determined to be a N,N-dimethylguanidium salt of psammaplin A sulfate and its bis-N,N-dimethylguanidium disulfate derivative, respectively. Aplysinellin A (5) possesses an additional bromotyrosine-derived C-9 unit connected directly to the carbon framework of psammaplin A by a biphenylic Linkage while aplysinellin B (6) is the corresponding cyclic enol ether. These compounds exhibited moderate cytotoxicity and inhibitory activities against farnesyl protein transferase and leucine aminopeptidase. (C) 2000 Elsevier Science Ltd. All rights reserved.
ISSN
0040-4020
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/6020
DOI
10.1016/S0040-4020(00)00761-4
Bibliographic Citation
TETRAHEDRON, v.56, no.46, pp.9071 - 9077, 2000
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Subject
PSAMMAPLYSILLA; SULFATE
Keywords
bromotyrosines; psammaplins; aplysinellins; sponge; Aplysinella rhax
Type
Article
Language
English
Document Type
Article
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Related Researcher
Research Interests

Marine Natural Products,Organic Chemistry,해양천연물,유기화학

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