Dissemination of transferable AmpC-type beta-lactamase (CMY-10) in a Korean hospital SCIE SCOPUS
DC Field | Value | Language |
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dc.contributor.author | Lee, JH | - |
dc.contributor.author | Jung, HI | - |
dc.contributor.author | Jung, JH | - |
dc.contributor.author | Park, JS | - |
dc.contributor.author | Ahn, JB | - |
dc.contributor.author | Jeong, SH | - |
dc.contributor.author | Jeong, BC | - |
dc.contributor.author | Lee, JH | - |
dc.contributor.author | Lee, SH | - |
dc.date.accessioned | 2020-04-20T14:55:07Z | - |
dc.date.available | 2020-04-20T14:55:07Z | - |
dc.date.created | 2020-01-28 | - |
dc.date.issued | 2004-09 | - |
dc.identifier.issn | 1076-6294 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/5173 | - |
dc.description.abstract | To determine dissemination and genotype of AmpC beta-lactamases and an extended-spectrum beta-lactamase among clinical isolates of Enterobacteriaceae, we performed antibiotic susceptibility testing, pI determination, induction test, plasmid profiles, transconjugation test, enterobacterial repetitive consensus (ERIC)-PCR, and DNA sequencing. Among the 51 clinical isolates collected from a university hospital in Korea, six isolates were resistant to cephamycins. All six isolates produced a plasmid-encoded AmpC-type beta-lactamase, CMY-10. Five strains also produced one or more other beta-lactamases: SHV-12, an extended-spectrum beta-lactamase (five isolates); TEM-1, a class A beta-lactamase (two isolates); and a chromosomal AmpC beta-lactamase (one isolate, a strain of Enterobacter aerogenes, which produced all four of the beta-lactamases that were identified). One of six isolates produced only CMY-10. ERIC-PCR analysis revealed that dissemination of CMY-10 and SHV-12 was due to a clonal outbreak of a resistant strain and to the interspecies spread of resistance to cephamycins and broad-spectrum beta-lactams in Korea. CMY-10 beta-lactamase genes that are responsible for the resistance to cephamycins (cefoxitin and cefotetan), amoxicillin, cephalothin, and amoxicillin-clavulanic acid were cloned and characterized from six clinical isolates. A sequence identical to the common regions in In6, In7, and a novel integron from pSAL-1 was found upstream from bla(CMY-10) gene at nucleotides 1-71. A total of 15 nucleotides (I-15) or 18 nucleotides (I-18) between position 71 and 72 were inserted into the bla(CMY-10) gene. The bla(CMY-10) gene might be inserted into a Bull-type complex integron by I-15 or I-18. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.title | Dissemination of transferable AmpC-type beta-lactamase (CMY-10) in a Korean hospital | - |
dc.type | Article | - |
dc.citation.endPage | 230 | - |
dc.citation.startPage | 224 | - |
dc.citation.title | MICROBIAL DRUG RESISTANCE | - |
dc.citation.volume | 10 | - |
dc.citation.number | 3 | - |
dc.contributor.alternativeName | 이정현 | - |
dc.identifier.bibliographicCitation | MICROBIAL DRUG RESISTANCE, v.10, no.3, pp.224 - 230 | - |
dc.identifier.doi | 10.1089/1076629041939319 | - |
dc.identifier.scopusid | 2-s2.0-4644340891 | - |
dc.identifier.wosid | 000223962700006 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI | - |
dc.subject.keywordPlus | KLEBSIELLA-PNEUMONIAE | - |
dc.subject.keywordPlus | CLINICAL ISOLATE | - |
dc.subject.keywordPlus | GENE CASSETTES | - |
dc.subject.keywordPlus | INFECTIONS | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | INTEGRON | - |
dc.subject.keywordPlus | ELEMENT | - |
dc.subject.keywordPlus | SHV-12 | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |