Transcriptomic profiling of Hydra magnipapillata after exposure to naproxen SCIE SCOPUS

Cited 2 time in WEB OF SCIENCE Cited 2 time in Scopus
Title
Transcriptomic profiling of Hydra magnipapillata after exposure to naproxen
Author(s)
Yamindago, Ade; Lee, Nayun; Woo, Seonock; Yum, Seungshic
KIOST Author(s)
Lee, Na Yun(이나윤)Yum, Seungshic(염승식)
Publication Year
2019-10
Abstract
The extensive use in humans and animals of nonsteroidal anti-inflammatory drugs (NSAIDs) increases their possible impact on aquatic organisms. In the present study, we investigated acute toxicity, morphological responses, and potential physiological and metabolic impacts of naproxen exposure on Hydra magnipapillata. The median lethal concentrations (LC50) of naproxen in H. magnipapillata were 51.999 mg/L, 44.935 mg/L, and 42.500 mg/L after exposure for 24, 48, and 72 h, respectively. Morphological observation of the exposed Hydra showed that 40 mg/L naproxen stimulated the contraction of body column and tentacles after 24 h. A KEGG pathway analysis of the genes differentially expressed in the Hydra after exposure to naproxen for 6, 24, or 48 h demonstrated various cellular and metabolic effects, including protein processing in the endoplasmic reticulum, Wnt signaling, and tryptophan metabolism. These results suggest that exposure to naproxen affects the genetic material, inflammatory processes, and metabolic processes of aquatic organisms.
ISSN
1382-6689
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/502
DOI
10.1016/j.etap.2019.103215
Bibliographic Citation
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, v.71, 2019
Publisher
ELSEVIER
Subject
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; NF-KAPPA-B; CHRONIC TOXICITY; GENE; DICLOFENAC; RESPONSES; PHARMACEUTICALS; NSAIDS; FISH
Keywords
Anti-inflammatory drug; Acute toxicity; Morphological changes; Protein degradation; DNA damage
Type
Article
Language
English
Document Type
Article
Publisher
ELSEVIER
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