Transcriptomic profiling of Hydra magnipapillata after exposure to naproxen
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Title
- Transcriptomic profiling of Hydra magnipapillata after exposure to naproxen
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Author(s)
- Yamindago, Ade; Lee, Nayun; Woo, Seonock; Yum, Seungshic
- KIOST Author(s)
- Woo, Seon Ock(우선옥); Yum, Seung Shic(염승식)
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Alternative Author(s)
- Ade Yamindago; 이나윤; 우선옥; 염승식
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Publication Year
- 2019-10
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Abstract
- The extensive use in humans and animals of nonsteroidal anti-inflammatory drugs (NSAIDs) increases their possible impact on aquatic organisms. In the present study, we investigated acute toxicity, morphological responses, and potential physiological and metabolic impacts of naproxen exposure on Hydra magnipapillata. The median lethal concentrations (LC50) of naproxen in H. magnipapillata were 51.999 mg/L, 44.935 mg/L, and 42.500 mg/L after exposure for 24, 48, and 72 h, respectively. Morphological observation of the exposed Hydra showed that 40 mg/L naproxen stimulated the contraction of body column and tentacles after 24 h. A KEGG pathway analysis of the genes differentially expressed in the Hydra after exposure to naproxen for 6, 24, or 48 h demonstrated various cellular and metabolic effects, including protein processing in the endoplasmic reticulum, Wnt signaling, and tryptophan metabolism. These results suggest that exposure to naproxen affects the genetic material, inflammatory processes, and metabolic processes of aquatic organisms.
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ISSN
- 1382-6689
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/502
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DOI
- 10.1016/j.etap.2019.103215
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Bibliographic Citation
- ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, v.71, 2019
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Publisher
- ELSEVIER
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Subject
- NONSTEROIDAL ANTIINFLAMMATORY DRUGS; NF-KAPPA-B; CHRONIC TOXICITY; GENE; DICLOFENAC; RESPONSES; PHARMACEUTICALS; NSAIDS; FISH
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Keywords
- Anti-inflammatory drug; Acute toxicity; Morphological changes; Protein degradation; DNA damage
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Type
- Article
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Language
- English
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Document Type
- Article
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