Resorcinosides A and B, Glycosylated Alkylresorcinols from a Marine-Derived Strain of the Fungus Penicillium janthinellum SCIE SCOPUS

Cited 8 time in WEB OF SCIENCE Cited 7 time in Scopus
Title
Resorcinosides A and B, Glycosylated Alkylresorcinols from a Marine-Derived Strain of the Fungus Penicillium janthinellum
Author(s)
Choi, Byeoung-Kyu; Thi Hoai Trinh Phan; Hwang, Sunghoon; Oh, Dong-Chan; Kang, Jong Soon; Lee, Hwa-Sun; Thi Duy Ngoc Ngo; Thi Thanh Van Tran; Shin, Hee Jae
KIOST Author(s)
Choi, Byeoung Kyu(최병규)Lee, Hwa Sun(이화선)
Publication Year
2019-11
Abstract
Two new glycosylated alkylresorcinols, resorcinosides A (1) and B (2), were isolated from a strain of the fungus Penicillium janthinellum derived from a marine sediment sample collected from Cu Lao Cham Island, Vietnam. The structures of 1 and 2 were established by interpretation of 1D and 2D NMR and high-resolution ESIMS data, and their absolute configurations were confirmed by the coupling constant of the anomeric proton, acid hydrolysis, subsequent HPLC analysis, Mosher's method, and quantum-mechanics-based computational analysis of NMR chemical shifts. The structure elucidation indicated that 1 and 2 are new alkylresorcinols with D-glucose, and 2 has an a-pyrone moiety attached to the aromatic ring. Compound 1 exhibited cytotoxic activity against the NUGC-3 cancer cell line with a GI(50) value of 9.3 mu M.
ISSN
0163-3864
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/469
DOI
10.1021/acs.jnatprod.9b00776
Bibliographic Citation
JOURNAL OF NATURAL PRODUCTS, v.82, no.11, pp.3186 - 3190, 2019
Publisher
AMER CHEMICAL SOC
Subject
GLUCOSIDES; LEAVES; RYE
Type
Article
Language
English
Document Type
Article
Publisher
AMER CHEMICAL SOC
Related Researcher
Research Interests

Marine natural product,Marine microorganisms,해양천연물,해양미생물

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