Resorcinosides A and B, Glycosylated Alkylresorcinols from a Marine-Derived Strain of the Fungus Penicillium janthinellum
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Title
- Resorcinosides A and B, Glycosylated Alkylresorcinols from a Marine-Derived Strain of the Fungus Penicillium janthinellum
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Author(s)
- Choi, Byeoung-Kyu; Thi Hoai Trinh Phan; Hwang, Sunghoon; Oh, Dong-Chan; Kang, Jong Soon; Lee, Hwa-Sun; Thi Duy Ngoc Ngo; Thi Thanh Van Tran; Shin, Hee Jae
- KIOST Author(s)
- Lee, Hwa Sun(이화선); Shin, Hee Jae(신희재)
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Alternative Author(s)
- 최병규; 이화선; 신희재
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Publication Year
- 2019-11
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Abstract
- Two new glycosylated alkylresorcinols, resorcinosides A (1) and B (2), were isolated from a strain of the fungus Penicillium janthinellum derived from a marine sediment sample collected from Cu Lao Cham Island, Vietnam. The structures of 1 and 2 were established by interpretation of 1D and 2D NMR and high-resolution ESIMS data, and their absolute configurations were confirmed by the coupling constant of the anomeric proton, acid hydrolysis, subsequent HPLC analysis, Mosher's method, and quantum-mechanics-based computational analysis of NMR chemical shifts. The structure elucidation indicated that 1 and 2 are new alkylresorcinols with D-glucose, and 2 has an a-pyrone moiety attached to the aromatic ring. Compound 1 exhibited cytotoxic activity against the NUGC-3 cancer cell line with a GI(50) value of 9.3 mu M.
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ISSN
- 0163-3864
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/469
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DOI
- 10.1021/acs.jnatprod.9b00776
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Bibliographic Citation
- JOURNAL OF NATURAL PRODUCTS, v.82, no.11, pp.3186 - 3190, 2019
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Publisher
- AMER CHEMICAL SOC
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Subject
- GLUCOSIDES; LEAVES; RYE
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Type
- Article
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Language
- English
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Document Type
- Article
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