Aaptamines as sortase A inhibitors from the tropical sponge Aaptos aaptos SCIE SCOPUS
DC Field | Value | Language |
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dc.contributor.author | Jang, Kyoung Hwa | - |
dc.contributor.author | Chung, Soon-Chun | - |
dc.contributor.author | Shin, Jongheon | - |
dc.contributor.author | Lee, So-Hyoung | - |
dc.contributor.author | Kim, Tae-Im | - |
dc.contributor.author | Lee, Hyi-Seung | - |
dc.contributor.author | Oh, Ki-Bong | - |
dc.date.accessioned | 2020-04-20T11:40:20Z | - |
dc.date.available | 2020-04-20T11:40:20Z | - |
dc.date.created | 2020-01-28 | - |
dc.date.issued | 2007-10-01 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/4630 | - |
dc.description.abstract | Four aaptamines (1-4), 1H-benzo[de][1,6]-naphthyridine alkaloids, were isolated from the marine sponge Aoptos aaptos and their inhibitory activities against sortase A (SrtA), an enzyme that plays a key role in cell wall protein anchoring and virulence in Staphylococcus aureus, were evaluated. Isoaaptamine (2) was a potent inhibitor of SrtA, with an IC50 value of 3.7 +/- 0.2 mu g/mL. The suppression of fibronectin-binding activity by isoaaptamine (2) highlights its potential for the treatment of S. aureus infections via inhibition of SrtA activity. Our studies have identified a series of SrtA inhibitors, providing the basis for further development of potent inhibitors. (C) 2007 Elsevier Ltd. All rights reserved. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | STAPHYLOCOCCUS-AUREUS SORTASE | - |
dc.subject | SURFACE-PROTEINS | - |
dc.subject | CELL-WALL | - |
dc.subject | ANTINEOPLASTIC AGENTS | - |
dc.subject | TRANSPEPTIDASE | - |
dc.subject | ISOAAPTAMINE | - |
dc.subject | PATHOGENESIS | - |
dc.subject | CONVERSION | - |
dc.subject | VIRULENCE | - |
dc.subject | ENVELOPE | - |
dc.title | Aaptamines as sortase A inhibitors from the tropical sponge Aaptos aaptos | - |
dc.type | Article | - |
dc.citation.endPage | 5369 | - |
dc.citation.startPage | 5366 | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.volume | 17 | - |
dc.citation.number | 19 | - |
dc.contributor.alternativeName | 이희승 | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.17, no.19, pp.5366 - 5369 | - |
dc.identifier.doi | 10.1016/j.bmcl.2007.08.007 | - |
dc.identifier.scopusid | 2-s2.0-34548571879 | - |
dc.identifier.wosid | 000250041400015 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | STAPHYLOCOCCUS-AUREUS SORTASE | - |
dc.subject.keywordPlus | SURFACE-PROTEINS | - |
dc.subject.keywordPlus | CELL-WALL | - |
dc.subject.keywordPlus | ANTINEOPLASTIC AGENTS | - |
dc.subject.keywordPlus | TRANSPEPTIDASE | - |
dc.subject.keywordPlus | ISOAAPTAMINE | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | CONVERSION | - |
dc.subject.keywordPlus | VIRULENCE | - |
dc.subject.keywordPlus | ENVELOPE | - |
dc.subject.keywordAuthor | aaptamines | - |
dc.subject.keywordAuthor | sponge | - |
dc.subject.keywordAuthor | Aaptos aaptos | - |
dc.subject.keywordAuthor | Staphylococcus aureus | - |
dc.subject.keywordAuthor | sortase A inhibition | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |