Antimicrobial activities of the bromophenols from the red alga Odonthalia corymbifera and some synthetic derivatives SCIE SCOPUS
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, Ki-Bong | - |
dc.contributor.author | Lee, Ji Hye | - |
dc.contributor.author | Chung, Soon-Chun | - |
dc.contributor.author | Shin, Jongheon | - |
dc.contributor.author | Shin, Hee Jae | - |
dc.contributor.author | Kim, Hye-Kyeong | - |
dc.contributor.author | Lee, Hyi-Seung | - |
dc.date.accessioned | 2020-04-20T10:55:36Z | - |
dc.date.available | 2020-04-20T10:55:36Z | - |
dc.date.created | 2020-01-28 | - |
dc.date.issued | 2008-01-01 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/4553 | - |
dc.description.abstract | A series of bromophenols was obtained by isolation from red alga Odonthalia corymbifera and by reactions of bis(hydroxyphenyl)methanes with bromine. New bromophenols including 3,3,5,5'-tetrabromo-2,2',4,4'-tetrahydroxydiphenylmethane (10), a regioisomer of the potent antimicrobial natural product, together with known derivatives were synthesized in high yield. All of the isolated and synthesized compounds were tested for antimicrobial activity against Gram-negative, Gram-positive bacteria and fungi. The preliminary structure-activity relationship, to elucidate the essential structure requirements for antimicrobial activity, has been described. Among the isolated natural products 2,2',3,3'-tetrabromo-4,4',5,5'-tetrahydroxydiphenylmethane (4) was found to be the most active derivative against Candida albicans, Aspergillus fumigatus, Trichophyton rubrum, and Trichophyton mentagrophytes. The synthetic bromophenols 3,3'-dibromo-6,6'-dihydroxydiphenylmethane (13) and 3,3',5,5'-tetrabromo-6, 6'-dihydroxydiphenylmethane (14) showed potent antibacterial effect against Staphylococcus aureus, Bacillus subtilis, Micrococcus luteus. Proteus vulgaris, and Salmonella typhimurium. (C) 2007 Elsevier Ltd. All rights reserved. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | RHODOMELA-CONFERVOIDES | - |
dc.subject | SYMPHYOCLADIA-LATIUSCULA | - |
dc.subject | AGENTS | - |
dc.subject | ETHER | - |
dc.subject | LARIX | - |
dc.title | Antimicrobial activities of the bromophenols from the red alga Odonthalia corymbifera and some synthetic derivatives | - |
dc.type | Article | - |
dc.citation.endPage | 108 | - |
dc.citation.startPage | 104 | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.volume | 18 | - |
dc.citation.number | 1 | - |
dc.contributor.alternativeName | 이지혜 | - |
dc.contributor.alternativeName | 신희재 | - |
dc.contributor.alternativeName | 이희승 | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.18, no.1, pp.104 - 108 | - |
dc.identifier.doi | 10.1016/j.bmcl.2007.11.003 | - |
dc.identifier.scopusid | 2-s2.0-37549051744 | - |
dc.identifier.wosid | 000253720300015 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | RHODOMELA-CONFERVOIDES | - |
dc.subject.keywordPlus | SYMPHYOCLADIA-LATIUSCULA | - |
dc.subject.keywordPlus | AGENTS | - |
dc.subject.keywordPlus | ETHER | - |
dc.subject.keywordPlus | LARIX | - |
dc.subject.keywordAuthor | bromophenol | - |
dc.subject.keywordAuthor | red alga | - |
dc.subject.keywordAuthor | structure-activity relationship | - |
dc.subject.keywordAuthor | antimicrobial | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |