Antimicrobial activities of the bromophenols from the red alga Odonthalia corymbifera and some synthetic derivatives SCIE SCOPUS

Cited 96 time in WEB OF SCIENCE Cited 110 time in Scopus
Title
Antimicrobial activities of the bromophenols from the red alga Odonthalia corymbifera and some synthetic derivatives
Author(s)
Oh, Ki-Bong; Lee, Ji Hye; Chung, Soon-Chun; Shin, Jongheon; Shin, Hee Jae; Kim, Hye-Kyeong; Lee, Hyi-Seung
KIOST Author(s)
Lee, Hyi Seung(이희승)
Publication Year
2008-01-01
Abstract
A series of bromophenols was obtained by isolation from red alga Odonthalia corymbifera and by reactions of bis(hydroxyphenyl)methanes with bromine. New bromophenols including 3,3,5,5'-tetrabromo-2,2',4,4'-tetrahydroxydiphenylmethane (10), a regioisomer of the potent antimicrobial natural product, together with known derivatives were synthesized in high yield. All of the isolated and synthesized compounds were tested for antimicrobial activity against Gram-negative, Gram-positive bacteria and fungi. The preliminary structure-activity relationship, to elucidate the essential structure requirements for antimicrobial activity, has been described. Among the isolated natural products 2,2',3,3'-tetrabromo-4,4',5,5'-tetrahydroxydiphenylmethane (4) was found to be the most active derivative against Candida albicans, Aspergillus fumigatus, Trichophyton rubrum, and Trichophyton mentagrophytes. The synthetic bromophenols 3,3'-dibromo-6,6'-dihydroxydiphenylmethane (13) and 3,3',5,5'-tetrabromo-6, 6'-dihydroxydiphenylmethane (14) showed potent antibacterial effect against Staphylococcus aureus, Bacillus subtilis, Micrococcus luteus. Proteus vulgaris, and Salmonella typhimurium. (C) 2007 Elsevier Ltd. All rights reserved.
ISSN
0960-894X
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/4553
DOI
10.1016/j.bmcl.2007.11.003
Bibliographic Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.18, no.1, pp.104 - 108, 2008
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Subject
RHODOMELA-CONFERVOIDES; SYMPHYOCLADIA-LATIUSCULA; AGENTS; ETHER; LARIX
Keywords
bromophenol; red alga; structure-activity relationship; antimicrobial
Type
Article
Language
English
Document Type
Article
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Related Researcher
Research Interests

Marine Natural Products,Organic Chemistry,해양천연물,유기화학

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