Thiolactones and Δ8,9-Pregnene Steroids from the Marine-Derived Fungus Meira sp. 1210CH-42 and Their α-Glucosidase Inhibitory Activity SCIE SCOPUS
DC Field | Value | Language |
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dc.contributor.author | Shin, Hee Jae | - |
dc.contributor.author | Lee, Min Ah | - |
dc.contributor.author | Lee, Hwa Sun | - |
dc.contributor.author | Heo, Chang Su | - |
dc.date.accessioned | 2023-04-18T04:32:30Z | - |
dc.date.available | 2023-04-18T04:32:30Z | - |
dc.date.created | 2023-04-18 | - |
dc.date.issued | 2023-04 | - |
dc.identifier.issn | 1660-3397 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/44172 | - |
dc.description.abstract | The fungal genus Meira was first reported in 2003 and has mostly been found on land. This is the first report of second metabolites from the marine-derived yeast-like fungus Meira sp. One new thiolactone (1), along with one revised thiolactone (2), two new Δ8,9-steroids (4, 5), and one known Δ8,9-steroid (3), were isolated from the Meira sp. 1210CH-42. Their structures were elucidated based on the comprehensive spectroscopic data analysis of 1D, 2D NMR, HR-ESIMS, ECD calculations, and the pyridine-induced deshielding effect. The structure of 5 was confirmed by oxidation of 4 to semisynthetic 5. In the α-glucosidase inhibition assay, compounds 2–4 showed potent in vitro inhibitory activity with IC50 values of 148.4, 279.7, and 86.0 μM, respectively. Compounds 2–4 exhibited superior activity as compared to acarbose (IC50 = 418.9 μM). | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | Thiolactones and Δ8,9-Pregnene Steroids from the Marine-Derived Fungus Meira sp. 1210CH-42 and Their α-Glucosidase Inhibitory Activity | - |
dc.type | Article | - |
dc.citation.title | Marine Drugs | - |
dc.citation.volume | 21 | - |
dc.citation.number | 4 | - |
dc.contributor.alternativeName | 신희재 | - |
dc.contributor.alternativeName | 이민아 | - |
dc.contributor.alternativeName | 이화선 | - |
dc.contributor.alternativeName | 허창수 | - |
dc.identifier.bibliographicCitation | Marine Drugs, v.21, no.4 | - |
dc.identifier.doi | 10.3390/md21040246 | - |
dc.identifier.scopusid | 2-s2.0-85153857419 | - |
dc.identifier.wosid | 000980847700001 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordAuthor | marine fungus | - |
dc.subject.keywordAuthor | natural product | - |
dc.subject.keywordAuthor | Meira sp. | - |
dc.subject.keywordAuthor | thiolactone | - |
dc.subject.keywordAuthor | pregnene steroid | - |
dc.subject.keywordAuthor | epimer | - |
dc.subject.keywordAuthor | stereochemistry | - |
dc.subject.keywordAuthor | α-glucosidase inhibitor | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |