Therapeutic effect of decellularized matrix from fish skin to promote skin regeneration
DC Field | Value | Language |
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dc.contributor.author | Heo, Seong Yeong | - |
dc.contributor.author | Heo, Soo Jin | - |
dc.contributor.author | Jung, Won Kyo | - |
dc.date.accessioned | 2022-12-05T01:32:07Z | - |
dc.date.available | 2022-12-05T01:32:07Z | - |
dc.date.created | 2022-12-02 | - |
dc.date.issued | 2022-05-12 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/43536 | - |
dc.description.abstract | A cellular matrix derived from natural tissue functions as a highly biocompatible and versatile scaffold for wound healing application. It provides a complex and highly organized environment with biological signals and physical stimuli. Recently, various kinds of tissue/organ decellularized extracellular matrix (dECM) from bovine and porcine have been used as a biomedical applications to support tissue regeneration but inherit religious restrictions and risk of disease transmission to humans. Marine fish-derived dECM is seen as attractive alternatives due to their similarity to mammalian physiology, reduced biological risks, and less religious restrictions. The aim of this study was to derive a decellularized matrix from the Olive flounder (Paralichthys olivaceus) skin and evaluate its suitability as a wound healing application. Olive flounder skin was treated with a series of chemical treatments to remove cellular components. Decellularized fish skin (dFS) was characterized and evaluated in vivo to assess its biological activities. The mouse wound defect model was used to evaluate the in vivo performance of the dFS compared with decellularized porcine skin (dPS). The resultant dFS was shown to enhance wound healing compared with the no treatment group and dPS. This study suggests that dFS has potential in skin regenerative application. | - |
dc.description.uri | 2 | - |
dc.publisher | 한국수산과학회 | - |
dc.title | Therapeutic effect of decellularized matrix from fish skin to promote skin regeneration | - |
dc.type | Conference | - |
dc.citation.conferenceDate | 2022-05-12 | - |
dc.citation.conferencePlace | KO | - |
dc.citation.conferencePlace | 서귀포 KAL호텔 | - |
dc.citation.endPage | 129 | - |
dc.citation.startPage | 129 | - |
dc.citation.title | 2022년도 한국수산과학회 학술대회 | - |
dc.contributor.alternativeName | 허성영 | - |
dc.contributor.alternativeName | 허수진 | - |
dc.identifier.bibliographicCitation | 2022년도 한국수산과학회 학술대회, pp.129 | - |
dc.description.journalClass | 2 | - |