Synthesis and antimicrobial activities of halogenated bis(hydroxyphenyl) methanes SCIE SCOPUS
DC Field | Value | Language |
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dc.contributor.author | Oh, Ki-Bong | - |
dc.contributor.author | Lee, Ji Hye | - |
dc.contributor.author | Lee, Jong Wook | - |
dc.contributor.author | Yoon, Kyung-Mi | - |
dc.contributor.author | Chung, Soon-Chun | - |
dc.contributor.author | Jeon, Heung Bae | - |
dc.contributor.author | Shin, Jongheon | - |
dc.contributor.author | Lee, Hyi-Seung | - |
dc.date.accessioned | 2020-04-20T09:55:16Z | - |
dc.date.available | 2020-04-20T09:55:16Z | - |
dc.date.created | 2020-01-28 | - |
dc.date.issued | 2009-02-01 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/4330 | - |
dc.description.abstract | A series of halophenols was prepared by the reaction of bis(hydroxyphenyl) methanes with effective halogenating agents such as bromine and sulfuryl chloride. One of these compounds, a biologically active halophenol-2,2',3,3'-tetrabromo-4,4',5,5'-tetrahydroxydiphenylmethane (1)-frequently isolated from red algae, was synthesized for the first time. Other halophenols included several novel compounds, together with known derivatives that were synthesized from the phenolic intermediates, bis(3,4-dihydroxyphenyl) methane (5) and bis(2-hydroxyphenyl) methane (14). All of the synthesized compounds were tested for antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. The preliminary structure-activity relationship was investigated in order to determine the essential structural requirements for their antimicrobial activity. Of all these halophenols, 2,2',3,3',6-pentabromo-4,4',5,5'-tetrahydroxydiphenylmethane (8) was found to be the most active against Candida albicans, Aspergillus fumigatus, Trichophyton rubrum, and Trichophyton mentagrophytes while 3,3',5,5'-tetrachloro-2,2'-dihydroxydiphenylmethane (18) exerted a powerful antibacterial effect against Staphylococcus aureus, Bacillus subtilis, Micrococcus luteus, Proteus vulgaris, and Salmonella typhimurium. (C) 2008 Elsevier Ltd. All rights reserved. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | ALGA ODONTHALIA-CORYMBIFERA | - |
dc.subject | RED ALGA | - |
dc.subject | POLYSIPHONIA-URCEOLATA | - |
dc.subject | BROMOPHENOLS | - |
dc.title | Synthesis and antimicrobial activities of halogenated bis(hydroxyphenyl) methanes | - |
dc.type | Article | - |
dc.citation.endPage | 948 | - |
dc.citation.startPage | 945 | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.volume | 19 | - |
dc.citation.number | 3 | - |
dc.contributor.alternativeName | 이종욱 | - |
dc.contributor.alternativeName | 이희승 | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.19, no.3, pp.945 - 948 | - |
dc.identifier.doi | 10.1016/j.bmcl.2008.11.089 | - |
dc.identifier.scopusid | 2-s2.0-58549096889 | - |
dc.identifier.wosid | 000262707000086 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ALGA ODONTHALIA-CORYMBIFERA | - |
dc.subject.keywordPlus | RED ALGA | - |
dc.subject.keywordPlus | POLYSIPHONIA-URCEOLATA | - |
dc.subject.keywordPlus | BROMOPHENOLS | - |
dc.subject.keywordAuthor | Halophenols | - |
dc.subject.keywordAuthor | Antibacterial activity | - |
dc.subject.keywordAuthor | Antifungal activity | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |