5-Hydroxyindole-type alkaloids, as Candida albicans isocitrate lyase inhibitors, from the tropical sponge Hyrtios sp. SCIE SCOPUS

Cited 45 time in WEB OF SCIENCE Cited 50 time in Scopus
Title
5-Hydroxyindole-type alkaloids, as Candida albicans isocitrate lyase inhibitors, from the tropical sponge Hyrtios sp.
Author(s)
Lee, Hyi-Seung; Yoon, Kyung-Mi; Han, Yu-Ri; Lee, Kyung Jin; Chung, Soon-Chun; Kim, Tae-Im; Lee, So-Hyoung; Shin, Jongheon; Oh, Ki-Bong
KIOST Author(s)
Lee, Hyi Seung(이희승)
Publication Year
2009-02-15
Abstract
Chemical investigations of the tropical marine sponge Hyrtios sp. have resulted in the isolation of a new alkaloid, 1-carboxy-6-hydroxy-3,4-dihydro-beta-carboline (1) together with the known metabolites, 6-hydroxy-3,4-dihydro-1-oxo-beta-carboline (2), 5-hydroxy-1H-indole-3-carboxylic acid methyl ester (3), serotonin (4), hyrtiosin A (5), 5-hydroxyindole-3-carbaldehyde (6), and hyrtiosin B (7). Their structures were elucidated on the basis of mass spectrometry and detailed 2D NMR spectroscopic data. Hyrtiosin B ( 7) displayed a potent inhibitory activity against isocitrate lyase (ICL) of Candida albicans with an IC50 value of 89.0 mu M. (C) 2009 Elsevier Ltd. All rights reserved.
ISSN
0960-894X
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/4329
DOI
10.1016/j.bmcl.2009.01.017
Bibliographic Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.19, no.4, pp.1051 - 1053, 2009
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Subject
ALGA ODONTHALIA-CORYMBIFERA; ASPERGILLUS-NIGER; GLYOXYLATE CYCLE; BROMOPHENOLS; PRODUCTS; CULTURE
Keywords
Hyrtios sp.; Alkaloids; Candida albicans; Isocitrate lyase; Inhibitory activity
Type
Article
Language
English
Document Type
Article
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
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