Enhanced wound-healing capability with inherent antimicrobial activities of usnic acid incorporated poly(ε-caprolactone)/decellularized extracellular matrix nanofibrous scaffold SCIE

DC Field Value Language
dc.contributor.author Chandika, Pathum -
dc.contributor.author Khan, Fazlurrahman -
dc.contributor.author Heo, Seong Yeong -
dc.contributor.author Kim, Young-Mog -
dc.contributor.author Yi, Myunggi -
dc.contributor.author Jung, Won-Kyo -
dc.date.accessioned 2022-08-16T01:30:02Z -
dc.date.available 2022-08-16T01:30:02Z -
dc.date.created 2022-08-16 -
dc.date.issued 2022-09 -
dc.identifier.issn 2772-9508 -
dc.identifier.uri https://sciwatch.kiost.ac.kr/handle/2020.kiost/43135 -
dc.description.abstract An extracellular matrix-mimicking, biodegradable tissue-engineered skin substitute with improved antibacterial, antibiofilm, and wound healing capabilities is essential in skin tissue regeneration applications. The purpose of this study was to develop a novel biodegradable composite nanofibrous poly(ε-caprolactone) (PCL)/decellularized extracellular matrix (dECM) scaffolds loaded with usnic acid (UA); (PEU), where UA is employed as an antibacterial agent as well as a wound-healing accelerator. The architecture and fiber structure of the scaffolds were examined using scanning electron microscopy, and the results revealed that the average diameters decreased as the dECM content increased. The chemical composition, changes in the crystalline structure, homogeneity, and thermal stability of the nanofiber scaffolds with different material compositions were determined using Fourier-transform infrared spectroscopy, X-ray diffraction, differential scanning calorimetry, and thermogravimetric analysis, respectively. The composite nanofibrous scaffolds exhibited strong antibacterial activity against various bacterial species, such as Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus mutans, and Cutibactrium acnes, and fungal pathogens (such as Candida albicans). Additionally, the composite nanofibrous scaffolds exhibited biofilm inhibition properties against Klebsiella pneumoniae and Pseudomonas aeruginosa. An evaluation of the appearance of in vivo full-thickness excisional wounds treated with the composite nanofiber scaffolds, as well as a histological analysis of the wounds 21 days after surgery, revealed that treatment with nanofibrous PEU scaffolds enhanced wound healing. This study reveals that the proposed composite nanofibrous PEU scaffold has substantial potential for treating infectious full-thickness wounds. © 2022 -
dc.description.uri 1 -
dc.language English -
dc.publisher ELSEVIER -
dc.title Enhanced wound-healing capability with inherent antimicrobial activities of usnic acid incorporated poly(ε-caprolactone)/decellularized extracellular matrix nanofibrous scaffold -
dc.type Article -
dc.citation.title Biomaterials Advances -
dc.citation.volume 140 -
dc.contributor.alternativeName 허성영 -
dc.identifier.bibliographicCitation Biomaterials Advances, v.140 -
dc.identifier.doi 10.1016/j.bioadv.2022.213046 -
dc.identifier.scopusid 2-s2.0-85135514587 -
dc.type.docType Article -
dc.description.journalClass 1 -
dc.description.isOpenAccess N -
dc.subject.keywordAuthor Anti-biofilm -
dc.subject.keywordAuthor Antimicrobial -
dc.subject.keywordAuthor Decellularized extracellular matrix -
dc.subject.keywordAuthor Electrospune nanofiber -
dc.subject.keywordAuthor Full-thickness wound healing -
dc.subject.keywordAuthor PCL -
dc.subject.keywordAuthor Usnic acid -
dc.description.journalRegisteredClass scie -
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Jeju Research Institute > Jeju Marine Research Center > 1. Journal Articles
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