Alginate nanocapsules by water-in-oil emulsification and external gelation for drug delivery to fine dust stimulated keratinocytes SCIE SCOPUS
DC Field | Value | Language |
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dc.contributor.author | Fernando,Ilekuttige Priyan Shanura | - |
dc.contributor.author | Kirindage, Kirinde Gedara Isuru Sandanuwan | - |
dc.contributor.author | Jayasinghe, Arachchige Maheshika Kumari | - |
dc.contributor.author | Han, Eui Jeong | - |
dc.contributor.author | Lee, Chang-Moon | - |
dc.contributor.author | Heo, Soo Jin | - |
dc.contributor.author | Ahn, Ginnae | - |
dc.date.accessioned | 2022-08-01T00:30:01Z | - |
dc.date.available | 2022-08-01T00:30:01Z | - |
dc.date.created | 2022-08-01 | - |
dc.date.issued | 2022-10 | - |
dc.identifier.issn | 0141-8130 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/43114 | - |
dc.description.abstract | Methodologies for synthesizing drug-loaded alginate nanocapsules were optimized and indomethacin and phloroglucinol loading capacities were studied. Their biological effects were studied for ameliorating fine dust (FD) induced detrimental effects in keratinocytes. The 1 % alginate to oil phase ratio of 1:20 was the optimal parameter for water in oil emulsification. The oil phase was optimized to contain sunflower oil: span 80 ratios of 17:3. Nanocapsule drug encapsulation efficiencies were 36.91 ± 5.56 and 32.41 ± 4.05 % respectively for phloroglucinol (EG2P) and indomethacin (EG2I) while the loading capacities were 25.28 ± 3.36 and 23.15 ± 2.84 %. Dried nanocapsules indicated a 40–140 nm diameter range while their hydrodynamic diameter was 989.69 nm at pH 7.0. Nanocapsules swelling was pH-dependent and in releasing media of pH values 4.5, 7.4, and 8.5, the drug release indicated a complex mechanism of swelling, diffusion, and erosion while at pH 2.0 the drug release followed the non-Fickian release. EG2P and EG2I treatment dose-dependently lowered FD-induced intracellular ROS production, apoptosis and inflammatory responses mediated through the NF-κB pathway in FD stimulated HaCaT keratinocytes and reduced epidermal barrier degradation. Further research could investigate the use of this technique in formulating cosmeceuticals containing drug-loaded alginate nanocapsules for achieving controlled release. © 2022 | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | Elsevier B.V. | - |
dc.title | Alginate nanocapsules by water-in-oil emulsification and external gelation for drug delivery to fine dust stimulated keratinocytes | - |
dc.type | Article | - |
dc.citation.endPage | 114 | - |
dc.citation.startPage | 102 | - |
dc.citation.title | International Journal of Biological Macromolecules | - |
dc.citation.volume | 218 | - |
dc.contributor.alternativeName | 허수진 | - |
dc.identifier.bibliographicCitation | International Journal of Biological Macromolecules, v.218, pp.102 - 114 | - |
dc.identifier.doi | 10.1016/j.ijbiomac.2022.07.097 | - |
dc.identifier.scopusid | 2-s2.0-85134800147 | - |
dc.identifier.wosid | 000863107500001 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | PARTICULATE MATTER | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | POLLUTION | - |
dc.subject.keywordPlus | FUCOIDAN | - |
dc.subject.keywordAuthor | Alginate | - |
dc.subject.keywordAuthor | Fine dust | - |
dc.subject.keywordAuthor | Nanocapsules | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Polymer Science | - |