Phytochemical Characterization and Bioactivity Toward Breast Cancer Cells of Unhydrolyzed and Acid-Hydrolyzed Extracts of Fagonia indica SCIE SCOPUS

DC Field Value Language Miranda, Cristobal L. - Kumbi, Yadano - Wu, Wenbin - Lee, Hyi Seung - Reed, Ralph L. - Stevens, Jan F. - 2022-07-18T00:50:03Z - 2022-07-18T00:50:03Z - 2022-07-12 - 2022-07 -
dc.identifier.issn 1934-578X -
dc.identifier.uri -
dc.description.abstract Phytochemicals from the genus, Fagonia, have been attracting increasing attention due to their potential beneficial effects on human health. Fagonia species contain various types of phytochemicals such as flavonoids, alkaloids, saponins, terpenoids, coumarins and tannins. In this study, we investigated the phytochemical composition of unhydrolyzed and acid-hydrolyzed extracts of Fagonia indica and their bioactivity toward breast cancer MCF-7 cells in vitro. The results revealed that F. indica contains phytochemicals consistent with the reported phytochemical composition of this Fagonia species, with greater amounts of aglycones detected in the hydrolyzed extract. The crude extract of F. indica without acid hydrolysis was found to be ineffective in inhibiting the growth of MCF-7 cells at doses below 1000 µg/mL. However, after acid hydrolysis (to mimic gastro-intestinal hydrolysis), the F. indica extract became growth-inhibitory to MCF-7 cells as low as 10 µg/mL and the cytotoxicity increased with increasing dose and time of treatment. The results suggest that F. indica extracts contain phytochemicals in glycosidic forms whose aglycones are active as anti-proliferative agents toward breast cancer cells in vitro. -
dc.description.uri 1 -
dc.language English -
dc.publisher Natural Product Communications -
dc.title Phytochemical Characterization and Bioactivity Toward Breast Cancer Cells of Unhydrolyzed and Acid-Hydrolyzed Extracts of <i>Fagonia indica</i> -
dc.type Article -
dc.citation.title Natural product communications -
dc.citation.volume 17 -
dc.citation.number 7 -
dc.contributor.alternativeName 이희승 -
dc.identifier.bibliographicCitation Natural product communications, v.17, no.7 -
dc.identifier.doi 10.1177/1934578x221109426 -
dc.identifier.scopusid 2-s2.0-85133573098 -
dc.identifier.wosid 000827484400001 -
dc.description.journalClass 1 -
dc.description.isOpenAccess Y -
dc.subject.keywordAuthor aglycones -
dc.subject.keywordAuthor bioactivity -
dc.subject.keywordAuthor breast cancer -
dc.subject.keywordAuthor Fagonia indica -
dc.subject.keywordAuthor flavonoids -
dc.subject.keywordAuthor triterpenoids -
dc.subject.keywordAuthor Zygophyllum indicum -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
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Marine Resources Research Division > Marine Biotechnology Research Center > 1. Journal Articles
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