Phytochemical Characterization and Bioactivity Toward Breast Cancer Cells of Unhydrolyzed and Acid-Hydrolyzed Extracts of Fagonia indica SCIE SCOPUS

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Title
Phytochemical Characterization and Bioactivity Toward Breast Cancer Cells of Unhydrolyzed and Acid-Hydrolyzed Extracts of Fagonia indica
Author(s)
Miranda, Cristobal L.; Kumbi, Yadano; Wu, Wenbin; Lee, Hyi Seung; Reed, Ralph L.; Stevens, Jan F.
KIOST Author(s)
Lee, Hyi Seung(이희승)
Alternative Author(s)
이희승
Publication Year
2022-07
Abstract
Phytochemicals from the genus, Fagonia, have been attracting increasing attention due to their potential beneficial effects on human health. Fagonia species contain various types of phytochemicals such as flavonoids, alkaloids, saponins, terpenoids, coumarins and tannins. In this study, we investigated the phytochemical composition of unhydrolyzed and acid-hydrolyzed extracts of Fagonia indica and their bioactivity toward breast cancer MCF-7 cells in vitro. The results revealed that F. indica contains phytochemicals consistent with the reported phytochemical composition of this Fagonia species, with greater amounts of aglycones detected in the hydrolyzed extract. The crude extract of F. indica without acid hydrolysis was found to be ineffective in inhibiting the growth of MCF-7 cells at doses below 1000 µg/mL. However, after acid hydrolysis (to mimic gastro-intestinal hydrolysis), the F. indica extract became growth-inhibitory to MCF-7 cells as low as 10 µg/mL and the cytotoxicity increased with increasing dose and time of treatment. The results suggest that F. indica extracts contain phytochemicals in glycosidic forms whose aglycones are active as anti-proliferative agents toward breast cancer cells in vitro.
ISSN
1934-578X
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/43083
DOI
10.1177/1934578x221109426
Bibliographic Citation
Natural product communications, v.17, no.7, 2022
Publisher
Natural Product Communications
Keywords
aglycones; bioactivity; breast cancer; Fagonia indica; flavonoids; triterpenoids; Zygophyllum indicum
Type
Article
Language
English
Publisher
Natural Product Communications
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