Protective effect of fucoxanthin isolated from Sargassum siliquastrum on UV-B induced cell damage SCIE SCOPUS

DC Field Value Language
dc.contributor.author Heo, Soo-Jin -
dc.contributor.author Jeon, You-Jin -
dc.date.accessioned 2020-04-20T09:40:35Z -
dc.date.available 2020-04-20T09:40:35Z -
dc.date.created 2020-01-28 -
dc.date.issued 2009-05-04 -
dc.identifier.issn 1011-1344 -
dc.identifier.uri https://sciwatch.kiost.ac.kr/handle/2020.kiost/4290 -
dc.description.abstract Fucoxanthin is a carotenoid isolated from Sargassum siliquastrum and is considered to be one of major active compound of marine algae. In this study, we investigated and confirmed the protective effect of fucoxanthin on UV-B induced cell injury in human fibroblast via 2',7'-dichlorodihydrofluorescein diacetate (DCFH-DA), 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyltetrazolium bromide (MTT), and comet assays. Intracellular ROS generated by exposure to UV-B radiation, which was significantly decreased by addition with various concentrations of fucoxanthin. Cell survival rate was increased with fucoxanthin pre-treated cells, which was reached around 81.47% at 100 mu M, and the inhibitory effect of cell damage exhibited dose-dependent manner. Moreover, fucoxanthin having protective properties was demonstrated via Hoechst 33342/PI staining. Hence, on the basis of the above-mentioned studies, fucoxanthin has the ability to protect against oxidative stress induced by UV-B radiation and which might be applied to antioxidant and cosmeceutical industries. (C) 2008 Elsevier B.V. All rights reserved. -
dc.description.uri 1 -
dc.language English -
dc.publisher ELSEVIER SCIENCE SA -
dc.subject OXIDATIVE DNA-DAMAGE -
dc.subject HYDROGEN-PEROXIDE -
dc.subject STRAND BREAKS -
dc.subject APOPTOSIS -
dc.subject EXTRACT -
dc.subject ANTIOXIDANT -
dc.subject ASSAY -
dc.subject ALGA -
dc.subject SKIN -
dc.title Protective effect of fucoxanthin isolated from Sargassum siliquastrum on UV-B induced cell damage -
dc.type Article -
dc.citation.endPage 107 -
dc.citation.startPage 101 -
dc.citation.title JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY -
dc.citation.volume 95 -
dc.citation.number 2 -
dc.identifier.bibliographicCitation JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, v.95, no.2, pp.101 - 107 -
dc.identifier.doi 10.1016/j.jphotobiol.2008.11.011 -
dc.identifier.scopusid 2-s2.0-64149125149 -
dc.identifier.wosid 000265705100005 -
dc.type.docType Article -
dc.description.journalClass 1 -
dc.subject.keywordPlus OXIDATIVE DNA-DAMAGE -
dc.subject.keywordPlus HYDROGEN-PEROXIDE -
dc.subject.keywordPlus STRAND BREAKS -
dc.subject.keywordPlus APOPTOSIS -
dc.subject.keywordPlus EXTRACT -
dc.subject.keywordPlus ANTIOXIDANT -
dc.subject.keywordPlus ASSAY -
dc.subject.keywordPlus ALGA -
dc.subject.keywordPlus SKIN -
dc.subject.keywordAuthor Fucoxanthin -
dc.subject.keywordAuthor Sargassum siliquastrum -
dc.subject.keywordAuthor UV-B radiation -
dc.subject.keywordAuthor Oxidative stress -
dc.subject.keywordAuthor Cell damage -
dc.relation.journalWebOfScienceCategory Biochemistry & Molecular Biology -
dc.relation.journalWebOfScienceCategory Biophysics -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.relation.journalResearchArea Biochemistry & Molecular Biology -
dc.relation.journalResearchArea Biophysics -
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