Functional role of a novel algicidal compound produced by Pseudoruegeria sp. M32A2M on the harmful algae Alexandrium catenella SCIE SCOPUS

DC Field Value Language Ko, So-Ra - Jeong, Yujin - Cho, Sang-Hyeok - Lee, Eunju - Jeong, Bo-Seong - Baek, Seung Ho - Oh, Byung-Ha - Ahn, Chi-Yong - Oh, Hee-Mock - Cho, Byung-Kwan - Cho, Suhyung - 2022-05-01T23:30:00Z - 2022-05-01T23:30:00Z - 2022-05-02 - 2022-08 -
dc.identifier.issn 0045-6535 -
dc.identifier.uri -
dc.description.abstract A marine phytoplankton dinoflagellate, Alexandrium sp. is known to cause worldwide harmful algal blooms, resulting in paralytic shellfish poisoning. In this study, we isolated a novel compound secreted by the marine bacterium Pseudoruegeria sp. M32A2M, and showed that it displays algicidal activity against A. catenella (group I). The molecular structure of the compound was analyzed by using 1H nuclear magnetic resonance (NMR), 13C NMR, and gas chromatography-mass spectrometry, which revealed that the compound was a diketopiperazine, cyclo[Ala-Gly]. Cyclo[Ala-Gly] induced a rapid decrease in the active chlorophyll a content and maximal quantum yield of photosystem II, leading to membrane disintegration after 24 h of its treatment. It showed the highest algicidal effect against diketopiperazines and also showed specific algicidal activities against several dinoflagellate species, but not for diatom species. In particular, cyclo[Ala-Gly] caused the transcriptional downregulation of the photosynthesis-related membrane complex in A. catenella, but not in the diatom Chaetoceros simplex. Based on structural modeling, we elucidated that cyclo[Ala-Gly] has a structure similar to that of plastoquinone, which transfers electrons by binding to the photosystem II core proteins PsbA and PsbD. This suggests a novel role for cyclo[Ala-Gly] as a potential inhibitor of photosynthesis. © 2022 Elsevier Ltd -
dc.description.uri 1 -
dc.language English -
dc.publisher Elsevier Ltd -
dc.title Functional role of a novel algicidal compound produced by Pseudoruegeria sp. M32A2M on the harmful algae Alexandrium catenella -
dc.type Article -
dc.citation.title Chemosphere -
dc.citation.volume 300 -
dc.contributor.alternativeName 백승호 -
dc.identifier.bibliographicCitation Chemosphere, v.300 -
dc.identifier.doi 10.1016/j.chemosphere.2022.134535 -
dc.identifier.scopusid 2-s2.0-85128234999 -
dc.type.docType Article -
dc.description.journalClass 1 -
dc.description.isOpenAccess N -
dc.subject.keywordAuthor Alexandrium catenella -
dc.subject.keywordAuthor Algicidal bacteria -
dc.subject.keywordAuthor Algicides -
dc.subject.keywordAuthor Harmful algae -
dc.subject.keywordAuthor Harmful algal bloom -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
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South Sea Research Institute > Risk Assessment Research Center > 1. Journal Articles
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