Nitrogen-Containing Secondary Metabolites from a Deep-Sea Fungus Aspergillus unguis and Their Anti-Inflammatory Activity
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Title
- Nitrogen-Containing Secondary Metabolites from a Deep-Sea Fungus Aspergillus unguis and Their Anti-Inflammatory Activity
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Author(s)
- Anh, Cao Van; Yoon, Yeo Dae; Kang, Jong Soon; Lee, Hwa Sun; Heo, Chang Su; Shin, Hee Jae
- KIOST Author(s)
- Lee, Hwa Sun(이화선); Heo, Chang Su(허창수); Shin, Hee Jae(신희재)
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Alternative Author(s)
- Cao Van Anh; 이화선; 허창수; 신희재
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Publication Year
- 2022-03
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Abstract
- Aspergillus is well-known as the second-largest contributor of fungal natural products. Based on NMR guided isolation, three nitrogen-containing secondary metabolites, including two new compounds, variotin B (1) and coniosulfide E (2), together with a known compound, unguisin A (3), were isolated from the ethyl acetate (EtOAc) extract of the deep-sea fungus Aspergillus unguis IV17-109. The planar structures of 1 and 2 were elucidated by an extensive analysis of their spectroscopic data (HRESIMS, 1D and 2D NMR). The absolute configuration of 2 was determined by comparison of its optical rotation value with those of the synthesized analogs. Compound 2 is a rare, naturally occurring substance with an unusual cysteinol moiety. Furthermore, 1 showed moderate anti-inflammatory activity with an IC50 value of 20.0 µM. These results revealed that Aspergillus unguis could produce structurally diverse nitrogenous secondary metabolites, which can be used for further studies to find anti-inflammatory leads.
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ISSN
- 1660-3397
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/42405
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DOI
- 10.3390/md20030217
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Bibliographic Citation
- Marine Drugs, v.20, no.3, pp.217 - 224, 2022
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Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
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Keywords
- deep-sea fungus; A. unguis; variotin; coniosulfide; anti-inflammatory
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Type
- Article
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Language
- English
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Document Type
- Article
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