Anti-Allergic Effect of 3,4-Dihydroxybenzaldehyde Isolated from Polysiphonia morrowii in IgE/BSA-Stimulated Mast Cells and a Passive Cutaneous Anaphylaxis Mouse Model
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Title
- Anti-Allergic Effect of 3,4-Dihydroxybenzaldehyde Isolated from Polysiphonia morrowii in IgE/BSA-Stimulated Mast Cells and a Passive Cutaneous Anaphylaxis Mouse Model
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Author(s)
- Kim, Eun A; Han, Eui-Jeong; Kim, Jun Seong; Fernando, Ilekuttige Priyan Shanura; Oh, Jae-Young; Kim, Kil-Nam; Ahn, Ginnae; Heo, Soo Jin
- KIOST Author(s)
- Kim, Eun A(김은아); Kim, Jun Seong(김준성); Heo, Soo Jin(허수진)
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Alternative Author(s)
- 김은아; 김준성; 허수진
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Publication Year
- 2022-02
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Abstract
- In this study, we investigated the anti-allergic effects of 3,4-dihydroxybenzaldehyde (DHB) isolated from the marine red alga, Polysiphonia morrowii, in mouse bone-marrow-derived cultured mast cells (BMCMCs) and passive cutaneous anaphylaxis (PCA) in anti-dinitrophenyl (DNP) im-munoglobulin E (IgE)-sensitized mice. DHB inhibited IgE/bovine serum albumin (BSA)-induced BMCMCs degranulation by reducing the release of β-hexosaminidase without inducing cytotoxicity. Further, DHB dose-dependently decreased the IgE binding and high-affinity IgE receptor (FcεRI) expression and FcεRI-IgE binding on the surface of BMCMCs. Moreover, DHB suppressed the secretion and/or the expression of the allergic cytokines, interleukin (IL)-4, IL-5, IL-6, IL-13, and tumor necrosis factor (TNF)-α, and the chemokine, thymus activation-regulated chemokine (TARC), by regulating the phosphorylation of IκBα and the translocation of cytoplasmic NF-κB into the nucleus. Furthermore, DHB attenuated the passive cutaneous anaphylactic (PCA) reaction reducing the exuded Evans blue amount in the mouse ear stimulated by IgE/BSA. These results suggest that DHB is a potential therapeutic candidate for the prevention and treatment of type I allergic disorders. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
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ISSN
- 1660-3397
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/42365
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DOI
- 10.3390/md20020133
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Bibliographic Citation
- Marine Drugs, v.20, no.2, 2022
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Publisher
- MDPI
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Keywords
- 3,4-dihydroxybenzaldehyde; Bone marrow-derived cultured mast cells; Immunoglobulin E; Passive cutaneous anaphylaxis; Polysiphonia morrowii
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Type
- Article
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Language
- English
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Document Type
- Article
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