Identification of novel polar aryl hydrocarbon receptor agonists accumulated in liver of black-tailed gulls in Korea using advanced effect-directed analysis SCIE SCOPUS

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Title
Identification of novel polar aryl hydrocarbon receptor agonists accumulated in liver of black-tailed gulls in Korea using advanced effect-directed analysis
Author(s)
Cha, Jihyun; Hong, Seongjin; Gwak, Jiyun; Kim, Mungi; Lee, Junghyun; Kim, T.Taewoo; Han, Gi Myung; Hong, Sang Hee; Hur, Jin; Giesy, John P.; Khim, Jong Seong
KIOST Author(s)
Han, Gi Myung(한기명)Hong, Sang Hee(홍상희)
Alternative Author(s)
한기명; 홍상희
Publication Year
2022-05
Abstract
Although bioaccumulation of persistent organic pollutants in seabirds has been examined, few studies have been conducted to identify previously unidentified substances. Here, aryl hydrocarbon receptor (AhR) agonists were identified in livers of black-tailed gulls from South Korea using effect-directed analysis combined with full-scan screening analysis. Significant AhR-mediated potencies were observed in the polar fractions of liver extracts using H4IIE-luc bioassay. Eight known polar AhR agonists accounted for 11–20% of the total AhR-mediated potencies in the polar fractions; hydrocortisone and rutaecarpine were the major contributors. Twenty-two AhR agonist candidates in the polar fractions were identified using liquid chromatography–quadrupole time-of-flight mass spectrometry during a six-step selection process. Of these, [10]-gingerol, angelicin, corticosterone, eupatilin, etofenprox, oxadixyl, and tretinoin were identified as novel AhR agonists. The contribution to potencies increased with inclusion of novel AhR agonists (27–52%); corticosterone and [10]-gingerol contributed significantly. Quantitative structure-activity relationship suggested that the novel AhR agonists have other potential toxic effects, including carcinogenicity and mutagenicity. Polar AhR agonists have been used for pharmaceuticals and pesticides. Some novel AhR agonists have log KOW > 2 and log KOA ≥ 6, which indicates that these compounds can be biomagnified in air-breathing organisms, such as seabirds. © 2022 The Authors
ISSN
0304-3894
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/42276
DOI
10.1016/j.jhazmat.2022.128305
Bibliographic Citation
Journal of Hazardous Materials, v.429, 2022
Publisher
Elsevier B.V.
Keywords
Aryl hydrocarbon receptor; Biomagnification potential; Full-scan screening analysis; H4IIE-luc bioassay; Pharmaceutical
Type
Article
Language
English
Document Type
Article
Publisher
Elsevier B.V.
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