Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering
SCIE
SCOPUS
Cited 6 time in
WEB OF SCIENCE
Cited 14 time in
Scopus
-
Title
- Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering
-
Author(s)
- Kim, Tae-Hee; Heo, Seong-Yeong; Oh, Gun-Woo; Heo, Soo Jin; Jung , Won-Kyo
- KIOST Author(s)
- Heo, Soo Jin(허수진)
-
Alternative Author(s)
- 허수진
-
Publication Year
- 2021-05
-
Abstract
- Polydeoxyribonucleotides (PDRNs) are a family of DNA-derived drugs with a molecular weight ranging from 50 to 1500 kDa, which are mainly extracted from the sperm cells of salmon trout or chum salmon. Many pre-clinical and clinical studies have demonstrated the wound healing and anti-inflammatory properties of PDRN, which are mediated by the activation of adenosine A(2A) receptor and salvage pathways, in addition to promoting osteoblast activity, collagen synthesis, and angiogenesis. In fact, PDRN is already marketed due to its therapeutic properties against various wound healing- and inflammation-related diseases. Therefore, this review assessed the most recent trends in marine organism-derived PDRN using the Google Scholar search engine. Further, we summarized the current applications and pharmacological properties of PDRN to serve as a reference for the development of novel PDRN-based technologies.
-
ISSN
- 1660-3397
-
URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/42228
-
DOI
- 10.3390/md19060296
-
Bibliographic Citation
- MARINE DRUGS, v.19, no.6, 2021
-
Publisher
- MDPI
-
Subject
- ACHILLES-TENDON-INJURY; LUNG INJURY; LIPOPOLYSACCHARIDE; MODEL; PAIN
-
Keywords
- marine organisms; polydeoxyribonucleotide; biomedical engineering
-
Type
- Article
-
Language
- English
-
Document Type
- Review
- Files in This Item:
-
There are no files associated with this item.
Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.