Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering SCIE SCOPUS

Cited 6 time in WEB OF SCIENCE Cited 14 time in Scopus
Title
Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering
Author(s)
Kim, Tae-Hee; Heo, Seong-Yeong; Oh, Gun-Woo; Heo, Soo Jin; Jung , Won-Kyo
KIOST Author(s)
Heo, Soo Jin(허수진)
Alternative Author(s)
허수진
Publication Year
2021-05
Abstract
Polydeoxyribonucleotides (PDRNs) are a family of DNA-derived drugs with a molecular weight ranging from 50 to 1500 kDa, which are mainly extracted from the sperm cells of salmon trout or chum salmon. Many pre-clinical and clinical studies have demonstrated the wound healing and anti-inflammatory properties of PDRN, which are mediated by the activation of adenosine A(2A) receptor and salvage pathways, in addition to promoting osteoblast activity, collagen synthesis, and angiogenesis. In fact, PDRN is already marketed due to its therapeutic properties against various wound healing- and inflammation-related diseases. Therefore, this review assessed the most recent trends in marine organism-derived PDRN using the Google Scholar search engine. Further, we summarized the current applications and pharmacological properties of PDRN to serve as a reference for the development of novel PDRN-based technologies.
ISSN
1660-3397
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/42228
DOI
10.3390/md19060296
Bibliographic Citation
MARINE DRUGS, v.19, no.6, 2021
Publisher
MDPI
Subject
ACHILLES-TENDON-INJURY; LUNG INJURY; LIPOPOLYSACCHARIDE; MODEL; PAIN
Keywords
marine organisms; polydeoxyribonucleotide; biomedical engineering
Type
Article
Language
English
Document Type
Review
Files in This Item:
There are no files associated with this item.

qrcode

Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse