Anti-allergic effect of low molecular weight digest from abalone viscera on atopic dermatitis-induced nc/nga
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Title
- Anti-allergic effect of low molecular weight digest from abalone viscera on atopic dermatitis-induced nc/nga
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Author(s)
- Kim, Tae-Hee; Heo, Seong Yeong; Oh, Gun-Woo; Park, Won Sun; Choi, Il-Whan; Qian, Zhong-Ji; Jung, Won-Kyo
- KIOST Author(s)
- Heo, Seong Yeong(허성영)
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Alternative Author(s)
- 허성영
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Publication Year
- 2021-11
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Abstract
- Abalone viscera (AV) is one of the byproducts of the seafood processing industry. The low molecular weight (<5 kDa) peptides (LMW-AV) obtained from gastrointestinal digestion of AV could suppress allergenic responses on activated HMC-1 human mast cells in our previous study. Regarding the allergenic response of LMW-AV, in the present study, we further investigated the potential of oral administration of LMW-AV against atopic dermatitis (AD) in a dermatitis-induced model stimulated with Dermatophagoides farinae. The results demonstrated that the LMW-AV reduced a number of clinical symptoms, such as the severity of the dermatitis and serum immunoglobulin E levels. Moreover, LMW-AV could inhibit the expression of chemokines and cytokines. The histological analysis indicated that the LMW-AV has suppressed the eosinophil count and the mast cell infiltration into the upper dermis. The results suggest that LMW-AV can be considered as a promising candidate for AD treatment. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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ISSN
- 1660-3397
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/42106
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DOI
- 10.3390/md19110634
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Bibliographic Citation
- Marine Drugs, v.19, no.11, 2021
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Publisher
- MDPI
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Keywords
- Abalone viscera; Atopic dermatitis; Dermatophagoides farina; Gastrointestinal digest; Haliotis discus hannai
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Type
- Article
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Language
- English
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Document Type
- Article
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