Transcriptome dynamics in benzo[a]pyrene exposed Hydra SCIE SCOPUS KCI

DC Field Value Language Lee, Na Yun - Woo, Seon Ock - Lee, Na Young - Jo, Ye Jin - Yamindago, Ade - Yum, Seung Shic - 2022-01-19T10:31:13Z - 2022-01-19T10:31:13Z - 2022-01-14 - 2022-07 -
dc.identifier.issn 1738-642X -
dc.identifier.uri -
dc.description.abstract Backgrounds Benzo[a]pyrene (BaP) is a well-known ecotoxicant that induces a wide spectrum of toxic effects in organisms, including carcinogenicity, teratogenicity, genotoxicity, and immunotoxicity. Thus, re-evaluation of its acute toxic effects in gene expression at sublethal concentration in experimental animal is essential to understand and/or predict metabolic and physiological changes in an organism after exposure. Objectives To understand the changes in acute toxicity by exposure time, differential gene expression profiling of Hydra magnipapillata was performed by DNA microarray after exposure to BaP. Results The median lethal concentrations of the animals (LC50) were determined to be 78.5, 53.6, and 28.9 mg/L after exposure to BaP for 24, 48, and 72 h, respectively. Morphological responses of hydra polyps to 50 mg/L of BaP by exposure time were observed. The gene expression levels of molecular chaperones, antioxidative enzymes were altered at the early phase of the exposure. Transcription of the genes related to development and differentiation; apoptosis and necrosis were affected by the 4 h BaP exposure group. After 12 h exposure, developmental processes, immune responses, and ion transport in hydra polyp seemed to be affected, since the transcriptions of the genes that related to those biological processes were induced or repressed by BaP exposure. Neurotransmission might be suppressed, but tumorigenesis and carcinogenesis, the DNA repair process might be induced in the 24 h BaP-exposed hydra group. Finally, tumorigenesis and carcinogenesis, and the DNA repair process seemed to be induced after 48 h exposure. Conclusion We successfully demonstrated the dynamic response of Hydra to BaP by exposure time at transcription level. The results could extend our knowledge on acute toxic effect of BaP at sublethal conditions. -
dc.description.uri 1 -
dc.language English -
dc.publisher 대한독성 유전단백체 학회 -
dc.title Transcriptome dynamics in benzo[a]pyrene exposed Hydra -
dc.type Article -
dc.citation.endPage 358 -
dc.citation.startPage 349 -
dc.citation.title Molecular & Cellular Toxicology -
dc.citation.volume 18 -
dc.citation.number 3 -
dc.contributor.alternativeName 이나윤 -
dc.contributor.alternativeName 우선옥 -
dc.contributor.alternativeName 이나영 -
dc.contributor.alternativeName 조예진 -
dc.contributor.alternativeName 염승식 -
dc.identifier.bibliographicCitation Molecular & Cellular Toxicology, v.18, no.3, pp.349 - 358 -
dc.identifier.doi 10.1007/s13273-021-00203-z -
dc.identifier.scopusid 2-s2.0-85122502029 -
dc.identifier.wosid 000740201700001 -
dc.type.docType Article; Early Access -
dc.description.journalClass 1 -
dc.description.isOpenAccess N -
dc.subject.keywordPlus ZINC-OXIDE NANOPARTICLES -
dc.subject.keywordPlus MODEL SYSTEM -
dc.subject.keywordPlus GREEN-ALGAE -
dc.subject.keywordPlus EXPRESSION -
dc.subject.keywordPlus TOXICITY -
dc.subject.keywordPlus FAMILY -
dc.subject.keywordPlus NEUROPEPTIDE -
dc.subject.keywordPlus BIOACCUMULATION -
dc.subject.keywordPlus MECHANISMS -
dc.subject.keywordPlus PROTEINS -
dc.subject.keywordAuthor Polycyclic aromatic hydrocarbons -
dc.subject.keywordAuthor Toxicity -
dc.subject.keywordAuthor Differential gene expression -
dc.subject.keywordAuthor Cnidaria -
dc.relation.journalWebOfScienceCategory Biochemistry & Molecular Biology -
dc.relation.journalWebOfScienceCategory Toxicology -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.description.journalRegisteredClass kci -
dc.relation.journalResearchArea Biochemistry & Molecular Biology -
dc.relation.journalResearchArea Toxicology -
Appears in Collections:
Marine Resources Research Division > Marine Biotechnology Research Center > 1. Journal Articles
South Sea Research Institute > Risk Assessment Research Center > 1. Journal Articles
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