Antibacterial and Cytotoxic Phenolic Polyketides from Two Marine-Derived Fungal Strains of Aspergillus unguis SCIE SCOPUS

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Title
Antibacterial and Cytotoxic Phenolic Polyketides from Two Marine-Derived Fungal Strains of Aspergillus unguis
Author(s)
Anh, Cao Van; Kwon, Joo-Hee; Kang, Jong Soon; Lee, Hwa-Sun; Heo, Chang-Su; Shin, Hee Jae
KIOST Author(s)
ANH, CAO VAN(Cao Van Anh)Lee, Hwa Sun(이화선)Heo, Chang Su(허창수)
Alternative Author(s)
Cao Van Anh; 이화선; 허창수; 신희재
Publication Year
2022-01
Abstract
A chemical investigation on the EtOAc extracts from two marine-derived fungal strains of Aspergillus unguis resulted in the isolation of three previously undescribed phenolic polyketides including unguidepside C (1), aspersidone B (3), and agonodepside C (12), and their 14 known congeners. The structures of the new compounds were determined based on detailed analysis and comparison of their spectroscopic data with literature values, as well as Snatzke’s method. The new compounds (1, 3, and 12) displayed a significant anti-Gram-positive bacterial activity, with MIC values ranging from 5.3 to 22.1 µM. Additionally, the isolated compounds (1–11 and 13–16) were evaluated for their cytotoxicity against a panel of tumor cell lines. Most of them (except for 9) displayed cytotoxicity against all the tested cell lines, with IC50 values ranging from 2.5 to 46.9 µM.
ISSN
1424-8247
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/42044
DOI
10.3390/ph15010074
Bibliographic Citation
Pharmaceuticals, v.15, no.1, 2022
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Keywords
Aspergillus unguis; marine-derived fungus; phenolic polyketides; antibacterial; cytotoxicity
Type
Article
Language
English
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
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