Antibacterial and Cytotoxic Phenolic Polyketides from Two Marine-Derived Fungal Strains of Aspergillus unguis
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Title
- Antibacterial and Cytotoxic Phenolic Polyketides from Two Marine-Derived Fungal Strains of Aspergillus unguis
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Author(s)
- Anh, Cao Van; Kwon, Joo-Hee; Kang, Jong Soon; Lee, Hwa-Sun; Heo, Chang-Su; Shin, Hee Jae
- KIOST Author(s)
- Lee, Hwa Sun(이화선); Heo, Chang Su(허창수); Shin, Hee Jae(신희재)
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Alternative Author(s)
- Cao Van Anh; 이화선; 허창수; 신희재
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Publication Year
- 2022-01
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Abstract
- A chemical investigation on the EtOAc extracts from two marine-derived fungal strains of Aspergillus unguis resulted in the isolation of three previously undescribed phenolic polyketides including unguidepside C (1), aspersidone B (3), and agonodepside C (12), and their 14 known congeners. The structures of the new compounds were determined based on detailed analysis and comparison of their spectroscopic data with literature values, as well as Snatzke’s method. The new compounds (1, 3, and 12) displayed a significant anti-Gram-positive bacterial activity, with MIC values ranging from 5.3 to 22.1 µM. Additionally, the isolated compounds (1–11 and 13–16) were evaluated for their cytotoxicity against a panel of tumor cell lines. Most of them (except for 9) displayed cytotoxicity against all the tested cell lines, with IC50 values ranging from 2.5 to 46.9 µM.
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ISSN
- 1424-8247
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/42044
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DOI
- 10.3390/ph15010074
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Bibliographic Citation
- Pharmaceuticals, v.15, no.1, 2022
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Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
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Keywords
- marine-derived fungus; phenolic polyketides; antibacterial; cytotoxicity; Aspergillus unguis
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Type
- Article
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Language
- English
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Document Type
- Article
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