Anti-inflammatory effect of Tuberatolide B from Sargassum macrocarpum in RAW264.7 cells and zebrafish model
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Title
- Anti-inflammatory effect of Tuberatolide B from Sargassum macrocarpum in RAW264.7 cells and zebrafish model
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Author(s)
- Heo, Soo Jin; Kim, Eun A; Kang, Na Lae; Kim, Jun Seong
- KIOST Author(s)
- Heo, Soo Jin(허수진); Kim, Eun A(김은아); Kang, Na Lae(강나래); Kim, Jun Seong(김준성)
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Alternative Author(s)
- 허수진; 김은아; 강나래; 김준성
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Publication Year
- 2021-10-29
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Abstract
- Brown algae are known to contain rich anti-inflammatory compounds. The objective of this study was to identify anti- inflammatory compound in the Sargassum macrocarpum and anti-inflammatory effect of tuberatolide B (TTB) was investigated. TTB significantly suppressed the production of Nitric oxide (NO) and pro-inflammatory cytokines such as interleukin (IL)-6 and IL-1β. In addition, the mechanism involved in the inhibition of the inflammatory effect of LPS by TTB was investigated. The results showed that TTB aforementioned this effect through NF-κB and MAPKs phosphorylation pathways. We also assessed the anti-inflammatory activity of TTB using in vivo zebrafish model. In LPS-stimulated zebrafish, TTB enhanced survival and significantly inhibited the NO production and mRNA expression of inducible NO synthase. Therefore, anti-inflammatory activity of TTB against LPS in RAW264.7 cells and the zebrafish model was determined. These finding suggest that TTB may be used as functional anti-inflammatory foods and nutraceuticals.
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/41866
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Bibliographic Citation
- The KFN 50th Anniversary: 2021 KFN International Symposium and Annual Meeting, pp.542, 2021
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Publisher
- The Korean Society of Food Science and Nutrition
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Type
- Conference
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