Enhancement of skin immune activities of spirulina maxima by high pressure extraction process SCOPUS KCI

Title
Enhancement of skin immune activities of spirulina maxima by high pressure extraction process
Author(s)
Oh, S.H.; Kang, D.H.; Choi, W.Y.; Seo, Y.C.; Heo, S.J.; Abu, A.M.; Jeong, K.H.; Lee, H.Y.
KIOST Author(s)
Kang, Do-Hyung(강도형)Heo, Soo Jin(허수진)
Publication Year
2010
Abstract
A marine alga, Spirulina maxima, was extracted under high pressure and low temperature conditions at 500 MPa and 60°C for 5 and 10 min. A high pressure of 500 MPa was applied to improve process yields because of low temperature extraction. This method resulted in highest higher extraction yield of 26.1% (w/w) in comparison to those results obtained from conventional extraction methods which produced a yield of 17.6% (w/w) from water. The extracts from this process also showed 19% of low cytotoxicity against human normal fibroblast cells in adding 1.0 mg/ml of the highest concentration. The crude extract significantly reduced the production of Prostaglandin E2 (PGE2) from CCD-986sk cells and increased nitric oxide production by macrophages. These higher activities of enhancing skin immune functions were found to have high antioxidant extract properties, like a 98% increase in DPPH radical scavenging activity. The extracts from the high pressure process showed a higher elution of active components than other processes and generated new compounds based on HPLC analysis. This clearly indicates that the extracts from high pressure and low temperature conditions have higher skin immune activation properties that have not been previously reported.
ISSN
1598-141X
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/4174
DOI
10.4217/OPR.2010.32.2.157
Bibliographic Citation
Ocean and Polar Research, v.32, no.2, pp.157 - 164, 2010
Subject
alga; antioxidant; concentration (composition); extraction method; high pressure; immune response; low temperature; nitric oxide; skin; toxicity; algae; Spirulina maxima
Keywords
Antioxidant; High pressure; Low temperature; Skin immune activities; Spirulina maxima
Type
Article
Language
Korean
Document Type
Article
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