Isolation of Scalarane‐Type Sesterterpenoids from the Marine Sponge Dysidea sp. and Stereochemical Reassignment of 12‐epi‐phyllactone D/E SCIE SCOPUS
DC Field | Value | Language |
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dc.contributor.author | Shin, A Young | - |
dc.contributor.author | Son, Arang | - |
dc.contributor.author | Choi, Changhoon | - |
dc.contributor.author | Lee, Jihoon | - |
dc.date.accessioned | 2021-11-10T05:50:01Z | - |
dc.date.available | 2021-11-10T05:50:01Z | - |
dc.date.created | 2021-11-10 | - |
dc.date.issued | 2021-11 | - |
dc.identifier.issn | 1660-3397 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/41687 | - |
dc.description.abstract | The chemical investigation of the marine sponge Dysidea sp., which was collected from Bohol province in the Philippines, resulted in the identification of 15 new scalarane-type sesterterpenoids (1–14, 16), together with 15 known compounds. The chemical structures of the new compounds were elucidated based on NMR spectroscopy and HRMS. The structure of 12-epi-phyllactone D/E (15) isolated during this study was originally identified in 2007. However, careful inspection of our experimental 13C NMR spectrum revealed considerable discrepancies with the reported data at C-9, C-12, C-14, and C-23, leading to the correction of the reported compound to the C-12 epimer of 15, phyllactone D/E. The biological properties of compounds 1–16 were evaluated using the MDA-MB-231 cancer cell line. Compound 7, which bears a pentenone E-ring, exhibits significant cytotoxicity with a GI50 value of 4.21 mM. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | Isolation of Scalarane‐Type Sesterterpenoids from the Marine Sponge Dysidea sp. and Stereochemical Reassignment of 12‐epi‐phyllactone D/E | - |
dc.type | Article | - |
dc.citation.title | Marine Drugs | - |
dc.citation.volume | 19 | - |
dc.citation.number | 11 | - |
dc.contributor.alternativeName | 신아영 | - |
dc.contributor.alternativeName | 이지훈 | - |
dc.identifier.bibliographicCitation | Marine Drugs, v.19, no.11 | - |
dc.identifier.doi | 10.3390/md19110627 | - |
dc.identifier.scopusid | 2-s2.0-85119620065 | - |
dc.identifier.wosid | 000725522500001 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordAuthor | Dysidea | - |
dc.subject.keywordAuthor | sesterterpenoid | - |
dc.subject.keywordAuthor | scalarane | - |
dc.subject.keywordAuthor | marine sponge | - |
dc.subject.keywordAuthor | marine natural product | - |
dc.subject.keywordAuthor | anticancer activity | - |
dc.subject.keywordAuthor | stereochemistry reassignment | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |