Skin Antiaging Effects of the Fermented Outer Layers of Leaf Skin of Aloe barbadensis Miller Associated with the Enhancement of Mitochondrial Activities of UVb-Irradiated Human Skin Fibroblasts SCIE SCOPUS

DC Field Value Language Lee, Hyeonwoo - Choi, Woonyong - Ro, Hyangseon - Kim, Gyurae - Lee, Hyeonyong - 2021-06-29T00:50:14Z - 2021-06-29T00:50:14Z - 2021-06-23 - 2021-06 -
dc.identifier.issn 2076-3417 -
dc.identifier.uri -
dc.description.abstract This study is the first to show that increased mitochondrial activities improved the antiaging effects of Aloe vera leaf skin fermented by Lactobacillus plantarum on UVb-irradiated skin fibroblasts. The fermented extract (AF) increased the activities of mitochondrial reductase and the complex II and significantly reduced reactive oxygen species (ROS) production, even under UVb stress conditions, and also increased DPPH free radical scavenging activities compared with the hot water extract of outer layers of aloe leaf (AW) and quercetin itself. AF exerted a synergistic effect with quercetin and bioactive substances derived from the fermentation process. Moreover, mitochondrial activation of UVb-irradiated human skin fibroblasts by 0.3% (w/v) of the AF plays important roles in increasing collagen production up to 125 +/- 5.45% and decreasing MMP-1 secretion down to 69.41 +/- 2.63% of the control levels. The AF enhanced the upregulation of collagen gene expression, and this change was also greater than those induced by the AW and quercetin. Therefore, this study concludes that fermentation of the skin of aloe leaves increases the activation of mitochondria and inhibits the photo-aging of UVb-irradiated skin fibroblasts. -
dc.description.uri 1 -
dc.language English -
dc.publisher MDPI -
dc.subject MMP-1 EXPRESSION -
dc.subject EXTRACT -
dc.subject (-)-EPICATECHIN -
dc.subject ANTIOXIDANT -
dc.subject QUERCETIN -
dc.subject GROWTH -
dc.subject DAMAGE -
dc.subject DEATH -
dc.title Skin Antiaging Effects of the Fermented Outer Layers of Leaf Skin of Aloe barbadensis Miller Associated with the Enhancement of Mitochondrial Activities of UVb-Irradiated Human Skin Fibroblasts -
dc.type Article -
dc.citation.title APPLIED SCIENCES-BASEL -
dc.citation.volume 11 -
dc.citation.number 12 -
dc.contributor.alternativeName 최운용 -
dc.identifier.bibliographicCitation APPLIED SCIENCES-BASEL, v.11, no.12 -
dc.identifier.doi 10.3390/app11125660 -
dc.identifier.scopusid 2-s2.0-85108869577 -
dc.identifier.wosid 000665952000001 -
dc.type.docType Article -
dc.description.journalClass 1 -
dc.description.isOpenAccess N -
dc.subject.keywordPlus OXIDATIVE STRESS -
dc.subject.keywordPlus MMP-1 EXPRESSION -
dc.subject.keywordPlus EXTRACT -
dc.subject.keywordPlus (-)-EPICATECHIN -
dc.subject.keywordPlus ANTIOXIDANT -
dc.subject.keywordPlus QUERCETIN -
dc.subject.keywordPlus GROWTH -
dc.subject.keywordPlus DAMAGE -
dc.subject.keywordPlus DEATH -
dc.subject.keywordAuthor leaf skin of Aloe vera -
dc.subject.keywordAuthor mitochondrial activities -
dc.subject.keywordAuthor skin antiaging -
dc.subject.keywordAuthor lactic acid fermentation -
dc.relation.journalWebOfScienceCategory Chemistry, Multidisciplinary -
dc.relation.journalWebOfScienceCategory Engineering, Multidisciplinary -
dc.relation.journalWebOfScienceCategory Materials Science, Multidisciplinary -
dc.relation.journalWebOfScienceCategory Physics, Applied -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.relation.journalResearchArea Chemistry -
dc.relation.journalResearchArea Engineering -
dc.relation.journalResearchArea Materials Science -
dc.relation.journalResearchArea Physics -
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Jeju Research Institute > Jeju Marine Research Center > 1. Journal Articles
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