Skin Antiaging Effects of the Fermented Outer Layers of Leaf Skin of Aloe barbadensis Miller Associated with the Enhancement of Mitochondrial Activities of UVb-Irradiated Human Skin Fibroblasts SCIE SCOPUS

Cited 2 time in WEB OF SCIENCE Cited 2 time in Scopus
Title
Skin Antiaging Effects of the Fermented Outer Layers of Leaf Skin of Aloe barbadensis Miller Associated with the Enhancement of Mitochondrial Activities of UVb-Irradiated Human Skin Fibroblasts
Author(s)
Lee, Hyeonwoo; Choi, Woonyong; Ro, Hyangseon; Kim, Gyurae; Lee, Hyeonyong
KIOST Author(s)
Choi, Yong Woon(최운용)
Alternative Author(s)
최운용
Publication Year
2021-06
Abstract
This study is the first to show that increased mitochondrial activities improved the antiaging effects of Aloe vera leaf skin fermented by Lactobacillus plantarum on UVb-irradiated skin fibroblasts. The fermented extract (AF) increased the activities of mitochondrial reductase and the complex II and significantly reduced reactive oxygen species (ROS) production, even under UVb stress conditions, and also increased DPPH free radical scavenging activities compared with the hot water extract of outer layers of aloe leaf (AW) and quercetin itself. AF exerted a synergistic effect with quercetin and bioactive substances derived from the fermentation process. Moreover, mitochondrial activation of UVb-irradiated human skin fibroblasts by 0.3% (w/v) of the AF plays important roles in increasing collagen production up to 125 +/- 5.45% and decreasing MMP-1 secretion down to 69.41 +/- 2.63% of the control levels. The AF enhanced the upregulation of collagen gene expression, and this change was also greater than those induced by the AW and quercetin. Therefore, this study concludes that fermentation of the skin of aloe leaves increases the activation of mitochondria and inhibits the photo-aging of UVb-irradiated skin fibroblasts.
ISSN
2076-3417
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/41477
DOI
10.3390/app11125660
Bibliographic Citation
APPLIED SCIENCES-BASEL, v.11, no.12, 2021
Publisher
MDPI
Subject
OXIDATIVE STRESS; MMP-1 EXPRESSION; EXTRACT; (-)-EPICATECHIN; ANTIOXIDANT; QUERCETIN; GROWTH; DAMAGE; DEATH
Keywords
leaf skin of Aloe vera; mitochondrial activities; skin antiaging; lactic acid fermentation
Type
Article
Language
English
Document Type
Article
Publisher
MDPI
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