Red Sea Cucumber (Stichopus japonicus) Suppresses Cancer Progression by Promoting the ROS-Mediated Inhibition of the MAPK Pathway KCI OTHER

Title
Red Sea Cucumber (Stichopus japonicus) Suppresses Cancer Progression by Promoting the ROS-Mediated Inhibition of the MAPK Pathway
Author(s)
Kim, Junseong; Kim, Eun A; Kang, Nalae; Choi, Youn Kyung; Heo, Soo Jin
KIOST Author(s)
Kim, Jun Seong(김준성)Kim, Eun A(김은아)Kang, Na Lae(강나래)Heo, Soo Jin(허수진)
Alternative Author(s)
김준성; 김은아; 강나래; 허수진
Publication Year
2020-12
Abstract
Stichopus japonicas (red sea cucumbers) inhabit the coastal sea surrounding Jeju Island, South Korea, and are thought to have various medicinal properties. In this study, we investigated the anticancer activity of a red sea cucumber (S. japonicus) collected from Jeju Island. We obtained the red sea cucumber extract (RSCE), and observed that it inhibited the tumor cell growth and increased reactive oxygen species (ROS) production associated with the induction of apoptosis through the mitogen-activated protein kinase (MAPK) pathway in murine colon carcinoma cells (CT-26). Treatment with RSCE and N-acetylcysteine, which is a ROS scavenger, increased ROS production and apoptosis via the regulation by the MAPK pathway on the ERK and JNK compared with the nontreated group. Therefore, RSCE promotes ROS-mediated suppression of the ERK and JNK activation, and subsequently inhibits cancer progression, suggesting that RSCE may be beneficial in treating colon carcinoma.
ISSN
2383-5400
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/41388
Bibliographic Citation
Journal of Marine Bioscience and Biotechnology, v.12, no.2, pp.91 - 98, 2020
Publisher
(사)한국해양바이오학회
Keywords
Red sea cucumber; Cancer; ROS; MAPK pathway; Stichopus japonicas
Type
Article
Language
English
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