Enantioselective total synthesis of (+)-ieodomycin A, (+)-ieodomycin B, and their three stereoisomers
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Title
- Enantioselective total synthesis of (+)-ieodomycin A, (+)-ieodomycin B, and their three stereoisomers
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Author(s)
- Choi, Du-Bong; Choi, Hansol; Lee, Jihoon; Lee, Yeon Ju; Lee, Hyi Seung; Joo, Jung Min; Lee, Jong Seok
- KIOST Author(s)
- Lee, Ji Hoon(이지훈); Lee, Yeon Ju(이연주); Lee, Hyi Seung(이희승); Lee, Jong Seok(이종석)
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Alternative Author(s)
- 최한솔; 이지훈; 이연주; 이희승; 이종석
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Publication Year
- 2020-12-07
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Abstract
- We describe a divergent and enantioselective total synthesis of (+)-ieodomycin A and (+)-ieodomycin B with three stereoisomers. The main advantage of the present synthesis is the late-stage elaboration of the side chain, which would afford a wide range of structurally diverse analogs with interesting bioactivities.
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ISSN
- 1477-0520
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/41380
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DOI
- 10.1039/d0ob02107e
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Bibliographic Citation
- ORGANIC & BIOMOLECULAR CHEMISTRY, v.18, no.45, pp.9227 - 9230, 2020
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Publisher
- ROYAL SOC CHEMISTRY
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Subject
- STEREOSELECTIVE TOTAL-SYNTHESIS; CONCISE ASYMMETRIC-SYNTHESIS; MARINE NATURAL-PRODUCTS; DRUG DISCOVERY; IEODOMYCIN; CONSTRUCTION
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Type
- Article
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Language
- English
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Document Type
- Article
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