Low molecular weight fucoidan fraction ameliorates inflammation and deterioration of skin barrier in fine-dust stimulated keratinocytes
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Title
- Low molecular weight fucoidan fraction ameliorates inflammation and deterioration of skin barrier in fine-dust stimulated keratinocytes
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Author(s)
- Fernando, Ilekuttige Priyan Shanura; Dias, Mawalle Kankanamge Hasitha Madhawa; Madusanka, Dissanayaka Mudiyanselage Dinesh; Han, Eui Jeong; Kim, Min Ju; Heo, Soo Jin; Lee, Kyounghoon; Cheong, Sun Hee; Ahn, Ginnae
- KIOST Author(s)
- Heo, Soo Jin(허수진)
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Alternative Author(s)
- 허수진
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Publication Year
- 2021-01-31
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Abstract
- Recently evidence linking the effects of fine-dust (FD) on skin inflammation is exaggerating. Fucoidan derived from brown algae has great potential for ameliorating oxidative stress and inflammation. Herein, a fucoidan fraction (SHC4-6) was purified from an enzymatic (Celluclast) extract of an invasive seaweed, Sargassumhorneri following gradient ethanol precipitation and anion exchange chromatography. Effectiveness of SHC4-6 in ameliorating FD (from Beijing, China)-induced inflammatory responses in HaCaT keratinocytes and recovery of skin barrier dysfunction was evaluated. SHC4-6 was comprising of sulfated mannofucans with their molecular weights distributed around 45 kDa. SHC4-6 dose- dependently lowered ROS levels in FD-induced HaCaT keratinocytes, ameliorating viability at 50 mu g mL(-1). SHC4-6 downregulated inflammatory cytokines, tumor necrosis factor-alpha, interleukin (IL)-1 beta, -5, -6, -8, -13, interferon-gamma, and chemokines, macrophage-derived chemokine, eotaxin, and thymus and activation regulated chemokine by inhibiting mitogen-activated protein kinase and nuclear factor-kappa B pathways. SHC4-6 treatment ameliorated key tight junction proteins and skin hydration factors, depicting the effects of fucoidan in reducing FD-induced inflammation and skin barrier deterioration. With further studies in place, SHC4-6 could be used as an ingredient for developing cosmetics to relieve FD-induced skin inflammation. (C) 2020 Elsevier B.V. All rights reserved.
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ISSN
- 0141-8130
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/41364
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DOI
- 10.1016/j.ijbiomac.2020.11.115
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Bibliographic Citation
- INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, v.168, pp.620 - 630, 2021
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Publisher
- ELSEVIER
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Subject
- IN-VITRO ANTIOXIDANT; SARGASSUM-HORNERI; BROWN-ALGAE; EXPRESSION; FILAGGRIN; POLYSACCHARIDES; ACTIVATION; CYTOKINES; LORICRIN; ACID
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Keywords
- Fucoidan; Skin barrier; Fine-dust
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Type
- Article
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Language
- English
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Document Type
- Article
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