Type II 항동결단백질의 진화: 그 기원과 positive selection에 관한 연구
-
Title
- Type II 항동결단백질의 진화: 그 기원과 positive selection에 관한 연구
-
Alternative Title
- Evolution of TypeII Antifreeze Protein: its origin and positive selection mechanism
-
Author(s)
- 남기웅; 송정민; 김충곤; 이윤호
- KIOST Author(s)
- Kim, Choong Gon(김충곤); Lee, Youn Ho(이윤호)
-
Alternative Author(s)
- 송정민; 김충곤; 이윤호
-
Publication Year
- 2007-06-24
-
Abstract
- The type II AFPs consist of two subtypes, Calcium-dependent and Calcium-independent AFP. It is unclear whether they have a single or multiple origins. In this study, we made an attempt to investigate the phylogenetic relationships of the type II AFPs with sequence data, using MrBayes and PAML. The results show that the type II AFP are monophylogenetic, and that they have evolved through the positive selection mechanism. The positively selected sites are located not only the region homologous with CaBS (Ca2+-binding site)) in C-type lectin(the upper half), but also the lower half of the AFP molecule. These results suggest that the lower half be involved in ice-binding, supporting the hyphothesis based on quantum mechanics (Cheng Y. et. al., 2002), and site directed mutation (Loewen MC. et. al., 1998).
-
URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/41180
-
Bibliographic Citation
- 국제분자생물진화학회, 2007
-
Publisher
- 국제분자생물진화학회
-
Type
- Conference
-
Language
- English
- Files in This Item:
-
There are no files associated with this item.
Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.