Type II 항동결단백질의 진화: 그 기원과 positive selection에 관한 연구

Title
Type II 항동결단백질의 진화: 그 기원과 positive selection에 관한 연구
Alternative Title
Evolution of TypeII Antifreeze Protein: its origin and positive selection mechanism
Author(s)
남기웅; 송정민; 김충곤; 이윤호
KIOST Author(s)
Kim, Choong Gon(김충곤)Lee, Youn Ho(이윤호)
Publication Year
2007-06-24
Abstract
The type II AFPs consist of two subtypes, Calcium-dependent and Calcium-independent AFP. It is unclear whether they have a single or multiple origins. In this study, we made an attempt to investigate the phylogenetic relationships of the type II AFPs with sequence data, using MrBayes and PAML. The results show that the type II AFP are monophylogenetic, and that they have evolved through the positive selection mechanism. The positively selected sites are located not only the region homologous with CaBS (Ca2+-binding site)) in C-type lectin(the upper half), but also the lower half of the AFP molecule. These results suggest that the lower half be involved in ice-binding, supporting the hyphothesis based on quantum mechanics (Cheng Y. et. al., 2002), and site directed mutation (Loewen MC. et. al., 1998).
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/41180
Bibliographic Citation
국제분자생물진화학회, 2007
Publisher
국제분자생물진화학회
Type
Conference
Language
English
Publisher
국제분자생물진화학회
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