Nucleotide sequence comparison of a chromosome rearrangement on human chromosome 12 and the corresponding ape chromosomes SCIE SCOPUS

DC Field Value Language Shimada, MK - Kim, CG - Kitano, T - Ferrell, RE - Kohara, Y - Saitou, N - 2021-03-17T08:29:11Z - 2021-03-17T08:29:11Z - 2021-03-17T08:29:11Z - 2021-03-17T08:29:11Z - 2020-02-04 - 2005 -
dc.identifier.issn 1424-8581 -
dc.identifier.uri -
dc.description.abstract Chromosome rearrangement has been considered to be important in the evolutionary process. Here, we demonstrate the evolutionary relationship of the rearranged human chromosome 12 and the corresponding chromosome XII in apes (chimpanzee, bonobo, gorilla, orangutan, and gibbon) by examining PCR products derived from the breakpoints of inversions and by conducting shotgun sequencing of a gorilla fosmid clone containing the breakpoint and a "duplicated segment" (duplicon). We confirmed that a pair of 23-kb duplicons flank the breakpoints of inversions on the long and short arms of chimpanzee chromosome XII. Although only the 23-kb duplicon on the long arm of chimpanzee chromosome XII and its telomeric flanking sequence are found to be conserved among the hominoids (human, great apes, and gibbons), the duplicon on the short arm of chimpanzee chromosome XII is suggested to be the result of a duplication from that on the long arm. Furthermore, the shotgun sequencing of a gorilla fosmid indicated that the breakpoint on the long arm of the gorilla is located at a different position 1.9 kb from that of chimpanzee. The region is flanked by a sequence homologous to that of human chromosome 6q22. Our findings and sequence analysis suggest a close relationship between segmental duplication and chromosome rearrangement (or breakpoint of inversion) in Hominoidea. The role of the chromosome rearrangement in speciation is also discussed based on our new results. Copyright (C) 2005 S. Karger AG, Basel. -
dc.description.uri 1 -
dc.language English -
dc.publisher KARGER -
dc.subject HUMANS -
dc.subject CHIMPANZEES -
dc.subject EVOLUTION -
dc.subject SPECIATION -
dc.subject SUBSTITUTIONS -
dc.subject CONSTRUCTION -
dc.subject DUPLICATION -
dc.subject DIVERGENCE -
dc.subject GORILLA -
dc.title Nucleotide sequence comparison of a chromosome rearrangement on human chromosome 12 and the corresponding ape chromosomes -
dc.type Article -
dc.citation.endPage 90 -
dc.citation.startPage 83 -
dc.citation.volume 108 -
dc.citation.number 1-3 -
dc.identifier.bibliographicCitation CYTOGENETIC AND GENOME RESEARCH, v.108, no.1-3, pp.83 - 90 -
dc.identifier.doi 10.1159/000080805 -
dc.identifier.wosid 000226011700011 -
dc.type.docType Article -
dc.description.journalClass 1 -
dc.subject.keywordPlus PERICENTRIC-INVERSION -
dc.subject.keywordPlus HUMANS -
dc.subject.keywordPlus CHIMPANZEES -
dc.subject.keywordPlus EVOLUTION -
dc.subject.keywordPlus SPECIATION -
dc.subject.keywordPlus SUBSTITUTIONS -
dc.subject.keywordPlus CONSTRUCTION -
dc.subject.keywordPlus DUPLICATION -
dc.subject.keywordPlus DIVERGENCE -
dc.subject.keywordPlus GORILLA -
dc.relation.journalWebOfScienceCategory Cell Biology -
dc.relation.journalWebOfScienceCategory Genetics & Heredity -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.relation.journalResearchArea Cell Biology -
dc.relation.journalResearchArea Genetics & Heredity -
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Marine Environmental & Climate Research Division > Marine Ecosystem Research Center > 1. Journal Articles
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