Human Endogenous Retrovirus (HERV)-R family in primates: Chromosomal location, gene expression, and evolution SCIE SCOPUS
DC Field | Value | Language |
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dc.contributor.author | Kim, HS | - |
dc.contributor.author | Yi, JM | - |
dc.contributor.author | Hirai, H | - |
dc.contributor.author | Huh, JW | - |
dc.contributor.author | Jeong, MS | - |
dc.contributor.author | Jang, SB | - |
dc.contributor.author | Kim, CG | - |
dc.contributor.author | Saitou, N | - |
dc.contributor.author | Hyun, BH | - |
dc.contributor.author | Lee, WH | - |
dc.date.accessioned | 2021-03-17T08:28:52Z | - |
dc.date.accessioned | 2021-03-17T08:28:52Z | - |
dc.date.available | 2021-03-17T08:28:52Z | - |
dc.date.available | 2021-03-17T08:28:52Z | - |
dc.date.created | 2020-01-28 | - |
dc.date.issued | 2006-03-29 | - |
dc.identifier.issn | 0378-1119 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/40491 | - |
dc.description.abstract | Hitherto, full-length endogenous retrovirus (HERV)-R has been located at human chromosome 7q11.2, and mRNA and envelope proteins have been detected in placenta and a variety of other cell types. In the present study, using a probe derived from the gorilla fosmid library, we detected the paralogous locus (7q31.3) of the HERV-R em, gene in human chromosome 7q11.2, and also determined the chromosomal location in apes and Old World monkeys. The HERV-R gene was not detected in New World monkeys or prosimians with FISH and PCR analyses. We determined the sequences of the HERV-R env genes obtained from the genomic DNA of primates using PCR and sequencing tools. Except for a HERV-R env, sequence derived from gorilla DNA, the functional domains of putative envelope proteins are conserved, suggesting that those domains could have a functional capacity in the primate genome. In addition, we investigated the ent, gene expression of HERV-R in various human tissues and cancer cells. An RT-PCR approach indicated that the em, gene was expressed in several human tissues (brain, prostate, testis, kidney, placenta, thymus, and uterus) and cancer cells (RT4, BT-474, MCF7, OVCAR-3, LOX-IMVI, and AZ521). Taken together, our data could be of Great use for understanding the evolutionary dynamics of HERV-R through primate radiation as well as the implications of its functional role in human tissues and cancers cells. (c) 2005 Elsevier B.V. All rights reserved. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | TISSUE-SPECIFIC EXPRESSION | - |
dc.subject | ZINC-FINGER GENE | - |
dc.subject | HERV-K | - |
dc.subject | MESSENGER-RNAS | - |
dc.subject | ENVELOPE PROTEIN | - |
dc.subject | GREAT APES | - |
dc.subject | ERV3 | - |
dc.subject | CHORIOCARCINOMA | - |
dc.subject | SEQUENCES | - |
dc.subject | CELLS | - |
dc.title | Human Endogenous Retrovirus (HERV)-R family in primates: Chromosomal location, gene expression, and evolution | - |
dc.type | Article | - |
dc.citation.endPage | 42 | - |
dc.citation.startPage | 34 | - |
dc.citation.title | GENE | - |
dc.citation.volume | 370 | - |
dc.contributor.alternativeName | 김충곤 | - |
dc.identifier.bibliographicCitation | GENE, v.370, pp.34 - 42 | - |
dc.identifier.doi | 10.1016/j.gene.2005.11.008 | - |
dc.identifier.scopusid | 2-s2.0-33644864772 | - |
dc.identifier.wosid | 000236641700005 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | TISSUE-SPECIFIC EXPRESSION | - |
dc.subject.keywordPlus | ZINC-FINGER GENE | - |
dc.subject.keywordPlus | HERV-K | - |
dc.subject.keywordPlus | MESSENGER-RNAS | - |
dc.subject.keywordPlus | ENVELOPE PROTEIN | - |
dc.subject.keywordPlus | GREAT APES | - |
dc.subject.keywordPlus | ERV3 | - |
dc.subject.keywordPlus | CHORIOCARCINOMA | - |
dc.subject.keywordPlus | SEQUENCES | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | HERV-R | - |
dc.subject.keywordAuthor | primates | - |
dc.subject.keywordAuthor | FISH | - |
dc.subject.keywordAuthor | expression | - |
dc.subject.keywordAuthor | human tissues | - |
dc.subject.keywordAuthor | cancer cells | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |