No Distinction of Orthology/Paralogy between Human and Chimpanzee Rh Blood Group Genes SCIE SCOPUS

Cited 4 time in WEB OF SCIENCE Cited 2 time in Scopus
Title
No Distinction of Orthology/Paralogy between Human and Chimpanzee Rh Blood Group Genes
Author(s)
Kitano, Takashi; Kim, Choong-Gon; Blancher, Antoine; Saitou, Naruya
KIOST Author(s)
Kim, Choong Gon(김충곤)
Publication Year
2016-03
Abstract
On human (Homo sapiens) chromosome 1, there is a tandem duplication encompassing Rh blood group genes (Hosa_RHD and Hosa_RHCE). This duplication occurred in the common ancestor of humans, chimpanzees (Pan troglodytes), and gorillas, after splitting from their common ancestor with orangutans. Although several studies have been conducted on ape Rh blood group genes, the clear genome structures of the gene clusters remain unknown. Here, we determined the genome structure of the gene cluster of chimpanzee Rh genes by sequencing five BAC (Bacterial Artificial Chromosome) clones derived from chimpanzees. We characterized three complete loci (Patr_RH alpha, Patr_RH beta, and Patr_RH gamma). In the Patr_RH beta locus, a short version of the gene, which lacked the middle part containing exons 4-8, was observed. The Patr_RH alpha and Patr_RH beta genes were located on the locations corresponding to Hosa_RHD and Hosa_RHCE, respectively, and Patr_RH gamma was in the immediate vicinity of Patr_RH beta. Sequence comparisons revealed high sequence similarity between Patr_RH beta and Hosa_RHCE, while the chimpanzee Rh gene closest to Hosa_RHD was not Patr_RH alpha but rather Patr_RH gamma. The results suggest that rearrangements and gene conversions frequently occurred between these genes and that the classic orthology/paralogy dichotomy no longer holds between human and chimpanzee Rh blood group genes.
ISSN
1759-6653
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/40385
DOI
10.1093/gbe/evw022
Bibliographic Citation
GENOME BIOLOGY AND EVOLUTION, v.8, no.3, pp.519 - 527, 2016
Publisher
OXFORD UNIV PRESS
Subject
PHYLOGENETIC NETWORKS; MAXIMUM-LIKELIHOOD; NONHUMAN-PRIMATES; GROUP SYSTEM; GROUP LOCUS; FIBER-FISH; EVOLUTIONARY; SEQUENCE; DIVERSITY; ANTIGENS
Keywords
gene duplication; phylogeny; rearrangement
Type
Article
Language
English
Document Type
Article
Publisher
OXFORD UNIV PRESS
Related Researcher
Research Interests

Molecular genetics,Zooplankton diversity,Marine healthcare,해양생물 분자유전,동물플랑크톤 다양성,해양헬스케어

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