Bathing effects of east saline groundwater concentrates on allergic (atopic) dermatitis-like skin lesions induced by 2,4-dinitrochlorobenzene in hairless mice SCIE SCOPUS

Cited 3 time in WEB OF SCIENCE Cited 3 time in Scopus
Title
Bathing effects of east saline groundwater concentrates on allergic (atopic) dermatitis-like skin lesions induced by 2,4-dinitrochlorobenzene in hairless mice
Author(s)
Kim, Choong-Gon; Lee, Ji-Eun; Jeong, Da-Geum; Lee, Youn-Ho; Park, Sang-In; Lee, Dae-Geon; Han, Chang-Hyun; Kang, Su-Jin; Song, Chang-Hyun; Choi, Seong-Hun; Lee, Young-Joon; Ku, Sae-Kwang
KIOST Author(s)
Kim, Choong Gon(김충곤)Lee, Youn Ho(이윤호)
Alternative Author(s)
김충곤; 이윤호
Publication Year
2017-06
Abstract
In the present study, it was evaluated whether east saline groundwater concentration solution (ESGWc) exerted a favorable inhibitory effect on 2,4-dinitrochlorobenzene (DNCB)-induced allergic/atopic-like dermatitis (AD). AD was induced and boosted by sensitization with DNCB via topical application on the dorsal back skins. Mice with DNCB-induced AD were bathed in 100-, 200-and 400-fold diluted ESGWc. After 6 weeks bathing, changes to body weight, clinical skin severity scores, scratching behavior, serum total immunoglobulin (Ig)E levels, submandibular lymph node and spleen weights, splenic cytokine levels, skin cytokine mRNA expressions, antioxidant defense systems and superoxide anion productions were recorded to determine the effects of bathing on the histopathology of dorsal back skin tissues. All DNCB-induced mice demonstrated that the induction of AD through IgE-mediated hypersensitivities, oxidative stresses, activation of MMP and apoptosis of keratinocytes resulted in no significant differences in body weight between the different groups at each time point following initial sensitization. However, markers of DNCB-induced AD were significantly inhibited (P<0.05) in a concentration-dependent manner following bathing in all concentrations of ESGWc. The results obtained in the present study suggest that bathing in ESGWc may have favorable protective effects against DNCB-induced AD due to favorable systemic and local immunomodulatory effects, active cytoprotective anti-apoptotic effects, inhibitory effects of matrix metalloproteinase activity, and anti-inflammatory and antioxidative effects.
ISSN
1792-0981
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/40357
DOI
10.3892/etm.2017.4397
Bibliographic Citation
EXPERIMENTAL AND THERAPEUTIC MEDICINE, v.13, no.6, pp.3448 - 3466, 2017
Publisher
SPANDIDOS PUBL LTD
Subject
NC/NGA MICE; POLY(ADP-RIBOSE) POLYMERASE; MATRIX METALLOPROTEINASES; CYTOKINE PRODUCTION; LIPID-PEROXIDATION; OXIDATIVE STRESS; STRATUM-CORNEUM; THERMAL WATER; NITRIC-OXIDE; CELL-DEATH
Keywords
groundwater concentrates; allergic/atopic-like dermatitis; apoptosis; antioxidant; anti-inflammatory; immunomodulatory effects
Type
Article
Language
English
Document Type
Article
Publisher
SPANDIDOS PUBL LTD
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