An angiogenesis inhibitor isolated from a marine-derived actinomycete, Nocardiopsis sp 03N67
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Title
- An angiogenesis inhibitor isolated from a marine-derived actinomycete, Nocardiopsis sp 03N67
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Author(s)
- Shin, Hee Jae; Mondol, M. A. Mojid; Yu, Tae Kyung; Lee, Hyi-Seung; Lee, Yeon-Ju; Jung, Hye Jin; Kim, Jong Hyeon; Kwon, Ho Jeong
- KIOST Author(s)
- Shin, Hee Jae(신희재); Lee, Hyi Seung(이희승); Lee, Yeon Ju(이연주)
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Alternative Author(s)
- 신희재; Mondol Md; 이희승; 이연주
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Publication Year
- 2010-12-17
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Abstract
- Cyclo-(L-Pro-L-Met) was isolated from the fermentation broth of a marine-derived actinomycete Nocardiopsis sp. 03N67 by chromatographic analysis and showed anti-angiogenesis activity against human umbilical vein endothelial cells (HUVECs). The structure and absolute stereochemistry of this compound were determined based on extensive spectroscopic data analysis, and Marfey's method, respectively. (C) 2010 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
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ISSN
- 1874-3900
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/3993
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DOI
- 10.1016/j.phytol.2010.07.005
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Bibliographic Citation
- PHYTOCHEMISTRY LETTERS, v.3, no.4, pp.194 - 197, 2010
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Publisher
- ELSEVIER SCIENCE BV
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Subject
- IN-VITRO; DIKETOPIPERAZINES; METABOLITES; TUMORS; VIVO
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Keywords
- Marine actinomycetes; Angiogenesis inhibitors; HUVECs; Diketopiperazine; Cyclo-(L-Pro-L-Met)
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Type
- Article
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Language
- English
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Document Type
- Article
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