Heterologous Microarray Hybridization Used for Differential Gene Expression Profiling in Arochlor 1260-exposed Marine Medaka SCOPUS
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 원효경 | - |
dc.contributor.author | 우선옥 | - |
dc.contributor.author | 이애경 | - |
dc.contributor.author | 이건섭 | - |
dc.contributor.author | 이택견 | - |
dc.contributor.author | 염승식 | - |
dc.date.accessioned | 2020-12-10T08:02:19Z | - |
dc.date.available | 2020-12-10T08:02:19Z | - |
dc.date.created | 2020-05-21 | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 2005-9752 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/38901 | - |
dc.description.abstract | Differential gene expression profiling was performed by heterologous hybridization using a medaka cDNA microarray on the hepatic tissue of the marine medaka (Oryzias javanicus) after exposure to Arochlor 1260, a polychlorinated biphenyl (PCB), which is classified as a persistent organic pollutant. Twenty-eight differentially expressed candidate genes were identified; one was induced and 27 were repressed (P < 0.01). The genes were assembled into 10 groups based mainly on the Eukaryotic Othologous Groups classification. These isolated gene candidates were differentially expressed and therefore have great potential as molecular biomarkers for identifying environmental stressors. The results obtained in this study will allow future studies to assess the molecular mechanisms of Arochlor 1260 toxicity and to develop a systems biology approach to PCB stress biology. (PCB), which is classified as a persistent organic pollutant. Twenty-eight differentially expressed candidate genes were identified; one was induced and 27 were repressed (P < 0.01). The genes were assembled into 10 groups based mainly on the Eukaryotic Othologous Groups classification. These isolated gene candidates were differentially expressed and therefore have great potential as molecular biomarkers for identifying environmental stressors. The results obtained in this study will allow future studies to assess the molecular mechanisms of Arochlor 1260 toxicity and to develop a systems biology approach to PCB stress biology. | - |
dc.description.uri | 3 | - |
dc.language | English | - |
dc.publisher | Korean Society of Environmental Risk Assessment and Health Science | - |
dc.title | Heterologous Microarray Hybridization Used for Differential Gene Expression Profiling in Arochlor 1260-exposed Marine Medaka | - |
dc.title.alternative | Heterologous Microarray Hybridization Used for Differential Gene Expression Profiling in Arochlor 1260-exposed Marine Medaka | - |
dc.type | Article | - |
dc.citation.endPage | 138 | - |
dc.citation.startPage | 132 | - |
dc.citation.title | Toxicology and Environmental Health Sciences | - |
dc.citation.volume | 4 | - |
dc.citation.number | 2 | - |
dc.contributor.alternativeName | 원효경 | - |
dc.contributor.alternativeName | 우선옥 | - |
dc.contributor.alternativeName | 이나윤 | - |
dc.contributor.alternativeName | 이건섭 | - |
dc.contributor.alternativeName | 이택견 | - |
dc.contributor.alternativeName | 염승식 | - |
dc.identifier.bibliographicCitation | Toxicology and Environmental Health Sciences, v.4, no.2, pp.132 - 138 | - |
dc.identifier.scopusid | 2-s2.0-84873276005 | - |
dc.description.journalClass | 3 | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordAuthor | Arochlor 1260 | - |
dc.subject.keywordAuthor | Differential gene expression profile | - |
dc.subject.keywordAuthor | Heterologous hybridization | - |
dc.subject.keywordAuthor | Marine medaka | - |
dc.subject.keywordAuthor | Polychlorinated biphenyl (PCB) | - |
dc.description.journalRegisteredClass | scopus | - |