Transcriptional response of marine medaka (Oryzias javanicus) on exposure to toxaphene SCIE SCOPUS

Cited 7 time in WEB OF SCIENCE Cited 7 time in Scopus
Title
Transcriptional response of marine medaka (Oryzias javanicus) on exposure to toxaphene
Author(s)
Woo, Seonock; Yum, Seungshic
KIOST Author(s)
Yum, Seung Shic(염승식)
Publication Year
2011-04
Abstract
Differential gene expression profiles were established from the head and liver tissues of the marine medaka fish (Olyzias javanicus) after its exposure to toxaphene, a persistent organic pollutant and insecticide, using differential display polymerase chain reaction. Twenty-seven differentially expressed genes were identified, which were associated with the cytoskeleton, development, metabolism, nucleic acid/protein binding, and signal transduction. Among these genes, those encoding molecular biomarkers known to be involved in metabolism, ATP hydrolysis, and protein regulation were strongly induced at the transcription level, and genes encoding one structural protein subunit or involved in lipid metabolism were strongly downregulated. The same trends in gene expression changes were observed with real-time PCR analysis of 12 selected clones. The genes identified could be used as molecular biomarkers of biological responses to polychlorinated camphene contamination in aquatic environments. (C) 2011 Elsevier Inc. All rights reserved.
ISSN
1532-0456
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/3881
DOI
10.1016/j.cbpc.2010.12.006
Bibliographic Citation
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, v.153, no.3, pp.355 - 361, 2011
Publisher
ELSEVIER SCIENCE INC
Subject
DIFFERENTIAL GENE-EXPRESSION; HETEROLOGOUS MICROARRAY HYBRIDIZATION; HOMOCYSTEINE S-METHYLTRANSFERASE; HUMAN HEALTH IMPLICATIONS; ENVIRONMENTAL CONTAMINANTS; JAVANESE MEDAKA; ARCTIC CANADA; REGENERATION; CRYSTALLINS; METABOLISM
Keywords
Oryzias javanicus; Marine medaka; Toxaphene; Polychlorinated camphenes (PCCs); Differential gene expression profile; Differential display (DD-) PCR
Type
Article
Language
English
Document Type
Article
Publisher
ELSEVIER SCIENCE INC
Related Researcher
Research Interests

Marine Genomics,Environmental Genomics,Novel biomaterials,해양생물유전체,생태환경유전체,바이오신소재

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